Human brucellosis: Experience from a tertiary care hospital in southern India

• Published in: Tropical doctor 2018-10, Vol.48 (4), p.368-372
• Main Authors: Patra, Sudipta, KE, Vandana, Tellapragada, Chaitanya, Mukhopadhyay, Chiranjay
• Format: Article
• Language: English
• Subjects: Acute Disease; Adult; Anti-Bacterial Agents - therapeutic use; Brucella - isolation & purification; Brucellosis - complications; Brucellosis - diagnosis; Brucellosis - mortality; Brucellosis - therapy; Chronic Disease; Drug Therapy, Combination; Female; Fever - diagnosis; Humans; India - epidemiology; Logistic Models; Male; Middle Aged; Retrospective Studies; Tertiary Care Centers - statistics & numerical data
• ISSN: 0049-4755; 1758-1133
• DOI: 10.1177/0049475518788467

The aim of our study was to examine and compare the clinical presentations, complications, laboratory findings, treatment and outcome of patients with acute, subacute and chronic forms of brucellosis in a tertiary care setting. This hospital-based observational study was undertaken between April 2015 and March 2017. Patients diagnosed with brucellosis, either by blood culture and/or serology, were recruited. A total of 94 cases of brucellosis of acute, subacute and chronic forms were observed in 78.7%, 15.9% and 5.3%, respectively. Blood culture grew Brucella spp. in 70.2% cases. Serological tests showed positivity in 96.8% of the patients. Using multivariate logistic regression analysis, fever and upper back pain were significant predictors for both acute and chronic forms of the disease, respectively. There is a need to increase awareness and understand the local sero-epidemiological pattern of brucellosis as it is still little known.