Lactobacillus plantarum C29‐Fermented Soybean (DW2009) Alleviates Memory Impairment in 5XFAD Transgenic Mice by Regulating Microglia Activation and Gut Microbiota Composition

• Published in: Molecular nutrition & food research 2018-10, Vol.62 (20), p.e1800359-n/a
• Main Authors: Lee, Hae‐Ji, Hwang, Yun‐Ha, Kim, Dong‐Hyun
• Format: Article
• Language: English
• Subjects: Activation; Amyloid; Amyloid beta-Peptides - metabolism; Amyloid Precursor Protein Secretases - metabolism; amyloid‐β; Animals; Apoptosis; Brain; Brain - metabolism; Brain-derived neurotrophic factor; Brain-Derived Neurotrophic Factor - metabolism; Caspase; Caspase 3 - metabolism; Cognitive ability; Composition; Cyclic AMP Response Element-Binding Protein - metabolism; fermented defatted soybean; Fermented food; Gastrointestinal Microbiome - physiology; Impairment; Inhibition (psychology); Intestinal microflora; Lactobacilli; Lactobacillus plantarum; Lipopolysaccharides; Male; Memory; Memory Disorders - diet therapy; memory impairment; Mice; Mice, Transgenic; Microbiota; Microglia; Microglia - physiology; NF-kappa B - metabolism; Object recognition; Oral administration; Pattern recognition; Phosphorylation; Populations; Rodents; Soy Foods - microbiology; Soybeans; Transgenic mice; Transgenic plants; Water treatment
• ISSN: 1613-4125; 1613-4133
• DOI: 10.1002/mnfr.201800359

Scope The study aims to determine whether Lactobacillus plantarum C29‐fermented defatted soybean (FDS, DW2009) can attenuate memory impairment in 5XFAD transgenic (Tg) mice. Methods and results Oral administration of FDS or C29 increases cognitive function in Tg mice in passive avoidance, Y‐maze, novel object recognition, and Morris water maze tasks. FDS or C29 treatment significantly suppresses amyloid‐β, β/γ‐secretases, caspase‐3 expression, and NF‐κB activation, and activates microglia and apoptotic neuron cell populations, and increases BDNF expression in the brain. FDS or C29 treatment suppresses blood and fecal lipopolysaccharide levels and Enterobacteriaceae population and increases lactobacilli/bifidobacteria populations. Conclusion FDS and C29 alleviates the decrease in cognitive function and inhibited amyloid‐β expression in Tg mice by regulating microglia activation and gut microbiota composition. A major hallmark of Alzheimer's disease is cognitive impairment and amyloid‐β (Aβ) deposits in brain. In the present study, it is found that Lactobacillus plantarum C29‐fermented defatted soybean (FDS) and C29 alleviated cognitive function and inhibited amyloid‐β expression in 5XFAD transgenic mice by regulating microglia activation and gut microbiota composition.