Loading…

Zinc signaling and epilepsy

Evidence from both preclinical and clinical studies suggest the importance of zinc homeostasis in seizures/epilepsy. Undoubtedly, zinc, via modulation of a variety of targets, is necessary for maintaining the balance between neuronal excitation and inhibition, while an imbalance between excitation a...

Full description

Saved in:

Bibliographic Details
Published in:	Pharmacology & therapeutics (Oxford) 2019-01, Vol.193, p.156-177
Main Authors:	Doboszewska, Urszula, Młyniec, Katarzyna, Wlaź, Aleksandra, Poleszak, Ewa, Nowak, Gabriel, Wlaź, Piotr
Format:	Article
Language:	English
Subjects:	Animals Anticonvulsants - therapeutic use Brain - metabolism Epilepsy Epilepsy - drug therapy Epilepsy - metabolism GPR39 Homeostasis Humans Seizures Seizures - metabolism Signal Transduction Zinc Zinc - metabolism Zinc - pharmacology Zinc transporters
Citations:	Items that this one cites Items that cite this one
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

cited_by	cdi_FETCH-LOGICAL-c374t-babc9ed41d37c5c3b6074f46e878467ee251ca97bd404320aafbf6c7fc3fcefe3
cites	cdi_FETCH-LOGICAL-c374t-babc9ed41d37c5c3b6074f46e878467ee251ca97bd404320aafbf6c7fc3fcefe3
container_end_page	177
container_issue
container_start_page	156
container_title	Pharmacology & therapeutics (Oxford)
container_volume	193
creator	Doboszewska, Urszula Młyniec, Katarzyna Wlaź, Aleksandra Poleszak, Ewa Nowak, Gabriel Wlaź, Piotr
description	Evidence from both preclinical and clinical studies suggest the importance of zinc homeostasis in seizures/epilepsy. Undoubtedly, zinc, via modulation of a variety of targets, is necessary for maintaining the balance between neuronal excitation and inhibition, while an imbalance between excitation and inhibition underlies seizures. However, the relationship between zinc signaling and seizures/epilepsy is complex as both extracellular and intracellular zinc may produce either protective or detrimental effects. This review provides an overview of preclinical/behavioral, functional and molecular studies, as well as clinical data on the involvement of zinc in the pathophysiology and treatment of seizures/epilepsy. Furthermore, the potential of targeting elements associated with zinc signaling or homeostasis and zinc levels as a therapeutic strategy for epilepsy is discussed.
doi_str_mv	10.1016/j.pharmthera.2018.08.013
format	article
fullrecord	<record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2095536315</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0163725818301517</els_id><sourcerecordid>2095536315</sourcerecordid><originalsourceid>FETCH-LOGICAL-c374t-babc9ed41d37c5c3b6074f46e878467ee251ca97bd404320aafbf6c7fc3fcefe3</originalsourceid><addsrcrecordid>eNqFkEtLAzEUhYMotlZ_gSCzdDPjzSQzmVlq8QUFNwriJmQyN23KvEymQv-9Ka26FA6czXfu4R5CIgoJBZrfrJNhpVw7rtCpJAVaJBBE2RGZ0kKUcWDej8k0GItFmhUTcub9GgA4h_SUTBhQXkJZTsnlh-105O2yU43tlpHq6ggH2-Dgt-fkxKjG48XBZ-Tt4f51_hQvXh6f57eLWDPBx7hSlS6x5rRmQmeaVTkIbniOhSh4LhDTjGpViqrmwFkKSpnK5FoYzYxGg2xGrvd3B9d_btCPsrVeY9OoDvuNlymUWcZyRrOAFntUu957h0YOzrbKbSUFuZtGruXfNHI3jYQgykL06tCyqVqsf4M_WwTgbg9g-PXLopNeW-w01tahHmXd2_9bvgGHX3nk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2095536315</pqid></control><display><type>article</type><title>Zinc signaling and epilepsy</title><source>ScienceDirect Freedom Collection</source><creator>Doboszewska, Urszula ; Młyniec, Katarzyna ; Wlaź, Aleksandra ; Poleszak, Ewa ; Nowak, Gabriel ; Wlaź, Piotr</creator><creatorcontrib>Doboszewska, Urszula ; Młyniec, Katarzyna ; Wlaź, Aleksandra ; Poleszak, Ewa ; Nowak, Gabriel ; Wlaź, Piotr</creatorcontrib><description>Evidence from both preclinical and clinical studies suggest the importance of zinc homeostasis in seizures/epilepsy. Undoubtedly, zinc, via modulation of a variety of targets, is necessary for maintaining the balance between neuronal excitation and inhibition, while an imbalance between excitation and inhibition underlies seizures. However, the relationship between zinc signaling and seizures/epilepsy is complex as both extracellular and intracellular zinc may produce either protective or detrimental effects. This review provides an overview of preclinical/behavioral, functional and molecular studies, as well as clinical data on the involvement of zinc in the pathophysiology and treatment of seizures/epilepsy. Furthermore, the potential of targeting elements associated with zinc signaling or homeostasis and zinc levels as a therapeutic strategy for epilepsy is discussed.</description><identifier>ISSN: 0163-7258</identifier><identifier>EISSN: 1879-016X</identifier><identifier>DOI: 10.1016/j.pharmthera.2018.08.013</identifier><identifier>PMID: 30149099</identifier><language>eng</language><publisher>England: Elsevier Inc</publisher><subject>Animals ; Anticonvulsants - therapeutic use ; Brain - metabolism ; Epilepsy ; Epilepsy - drug therapy ; Epilepsy - metabolism ; GPR39 ; Homeostasis ; Humans ; Seizures ; Seizures - metabolism ; Signal Transduction ; Zinc ; Zinc - metabolism ; Zinc - pharmacology ; Zinc transporters</subject><ispartof>Pharmacology & therapeutics (Oxford), 2019-01, Vol.193, p.156-177</ispartof><rights>2018 Elsevier Inc.</rights><rights>Copyright © 2018 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c374t-babc9ed41d37c5c3b6074f46e878467ee251ca97bd404320aafbf6c7fc3fcefe3</citedby><cites>FETCH-LOGICAL-c374t-babc9ed41d37c5c3b6074f46e878467ee251ca97bd404320aafbf6c7fc3fcefe3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30149099$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Doboszewska, Urszula</creatorcontrib><creatorcontrib>Młyniec, Katarzyna</creatorcontrib><creatorcontrib>Wlaź, Aleksandra</creatorcontrib><creatorcontrib>Poleszak, Ewa</creatorcontrib><creatorcontrib>Nowak, Gabriel</creatorcontrib><creatorcontrib>Wlaź, Piotr</creatorcontrib><title>Zinc signaling and epilepsy</title><title>Pharmacology & therapeutics (Oxford)</title><addtitle>Pharmacol Ther</addtitle><description>Evidence from both preclinical and clinical studies suggest the importance of zinc homeostasis in seizures/epilepsy. Undoubtedly, zinc, via modulation of a variety of targets, is necessary for maintaining the balance between neuronal excitation and inhibition, while an imbalance between excitation and inhibition underlies seizures. However, the relationship between zinc signaling and seizures/epilepsy is complex as both extracellular and intracellular zinc may produce either protective or detrimental effects. This review provides an overview of preclinical/behavioral, functional and molecular studies, as well as clinical data on the involvement of zinc in the pathophysiology and treatment of seizures/epilepsy. Furthermore, the potential of targeting elements associated with zinc signaling or homeostasis and zinc levels as a therapeutic strategy for epilepsy is discussed.</description><subject>Animals</subject><subject>Anticonvulsants - therapeutic use</subject><subject>Brain - metabolism</subject><subject>Epilepsy</subject><subject>Epilepsy - drug therapy</subject><subject>Epilepsy - metabolism</subject><subject>GPR39</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>Seizures</subject><subject>Seizures - metabolism</subject><subject>Signal Transduction</subject><subject>Zinc</subject><subject>Zinc - metabolism</subject><subject>Zinc - pharmacology</subject><subject>Zinc transporters</subject><issn>0163-7258</issn><issn>1879-016X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNqFkEtLAzEUhYMotlZ_gSCzdDPjzSQzmVlq8QUFNwriJmQyN23KvEymQv-9Ka26FA6czXfu4R5CIgoJBZrfrJNhpVw7rtCpJAVaJBBE2RGZ0kKUcWDej8k0GItFmhUTcub9GgA4h_SUTBhQXkJZTsnlh-105O2yU43tlpHq6ggH2-Dgt-fkxKjG48XBZ-Tt4f51_hQvXh6f57eLWDPBx7hSlS6x5rRmQmeaVTkIbniOhSh4LhDTjGpViqrmwFkKSpnK5FoYzYxGg2xGrvd3B9d_btCPsrVeY9OoDvuNlymUWcZyRrOAFntUu957h0YOzrbKbSUFuZtGruXfNHI3jYQgykL06tCyqVqsf4M_WwTgbg9g-PXLopNeW-w01tahHmXd2_9bvgGHX3nk</recordid><startdate>201901</startdate><enddate>201901</enddate><creator>Doboszewska, Urszula</creator><creator>Młyniec, Katarzyna</creator><creator>Wlaź, Aleksandra</creator><creator>Poleszak, Ewa</creator><creator>Nowak, Gabriel</creator><creator>Wlaź, Piotr</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201901</creationdate><title>Zinc signaling and epilepsy</title><author>Doboszewska, Urszula ; Młyniec, Katarzyna ; Wlaź, Aleksandra ; Poleszak, Ewa ; Nowak, Gabriel ; Wlaź, Piotr</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c374t-babc9ed41d37c5c3b6074f46e878467ee251ca97bd404320aafbf6c7fc3fcefe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Animals</topic><topic>Anticonvulsants - therapeutic use</topic><topic>Brain - metabolism</topic><topic>Epilepsy</topic><topic>Epilepsy - drug therapy</topic><topic>Epilepsy - metabolism</topic><topic>GPR39</topic><topic>Homeostasis</topic><topic>Humans</topic><topic>Seizures</topic><topic>Seizures - metabolism</topic><topic>Signal Transduction</topic><topic>Zinc</topic><topic>Zinc - metabolism</topic><topic>Zinc - pharmacology</topic><topic>Zinc transporters</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Doboszewska, Urszula</creatorcontrib><creatorcontrib>Młyniec, Katarzyna</creatorcontrib><creatorcontrib>Wlaź, Aleksandra</creatorcontrib><creatorcontrib>Poleszak, Ewa</creatorcontrib><creatorcontrib>Nowak, Gabriel</creatorcontrib><creatorcontrib>Wlaź, Piotr</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmacology & therapeutics (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Doboszewska, Urszula</au><au>Młyniec, Katarzyna</au><au>Wlaź, Aleksandra</au><au>Poleszak, Ewa</au><au>Nowak, Gabriel</au><au>Wlaź, Piotr</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Zinc signaling and epilepsy</atitle><jtitle>Pharmacology & therapeutics (Oxford)</jtitle><addtitle>Pharmacol Ther</addtitle><date>2019-01</date><risdate>2019</risdate><volume>193</volume><spage>156</spage><epage>177</epage><pages>156-177</pages><issn>0163-7258</issn><eissn>1879-016X</eissn><abstract>Evidence from both preclinical and clinical studies suggest the importance of zinc homeostasis in seizures/epilepsy. Undoubtedly, zinc, via modulation of a variety of targets, is necessary for maintaining the balance between neuronal excitation and inhibition, while an imbalance between excitation and inhibition underlies seizures. However, the relationship between zinc signaling and seizures/epilepsy is complex as both extracellular and intracellular zinc may produce either protective or detrimental effects. This review provides an overview of preclinical/behavioral, functional and molecular studies, as well as clinical data on the involvement of zinc in the pathophysiology and treatment of seizures/epilepsy. Furthermore, the potential of targeting elements associated with zinc signaling or homeostasis and zinc levels as a therapeutic strategy for epilepsy is discussed.</abstract><cop>England</cop><pub>Elsevier Inc</pub><pmid>30149099</pmid><doi>10.1016/j.pharmthera.2018.08.013</doi><tpages>22</tpages></addata></record>
fulltext	fulltext
identifier	ISSN: 0163-7258
ispartof	Pharmacology & therapeutics (Oxford), 2019-01, Vol.193, p.156-177
issn	0163-7258 1879-016X
language	eng
recordid	cdi_proquest_miscellaneous_2095536315
source	ScienceDirect Freedom Collection
subjects	Animals Anticonvulsants - therapeutic use Brain - metabolism Epilepsy Epilepsy - drug therapy Epilepsy - metabolism GPR39 Homeostasis Humans Seizures Seizures - metabolism Signal Transduction Zinc Zinc - metabolism Zinc - pharmacology Zinc transporters
title	Zinc signaling and epilepsy
url	http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T13%3A34%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Zinc%20signaling%20and%20epilepsy&rft.jtitle=Pharmacology%20&%20therapeutics%20(Oxford)&rft.au=Doboszewska,%20Urszula&rft.date=2019-01&rft.volume=193&rft.spage=156&rft.epage=177&rft.pages=156-177&rft.issn=0163-7258&rft.eissn=1879-016X&rft_id=info:doi/10.1016/j.pharmthera.2018.08.013&rft_dat=%3Cproquest_cross%3E2095536315%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c374t-babc9ed41d37c5c3b6074f46e878467ee251ca97bd404320aafbf6c7fc3fcefe3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2095536315&rft_id=info:pmid/30149099&rfr_iscdi=true