Platelet–lymphocyte Ratio After Granulocyte Colony Stimulating Factor Administration: an Early Prognostic Marker in Septic Shock Patients With Chemotherapy-Induced Febrile Neutropenia

INTRODUCTION:Chemotherapy-induced febrile neutropenia (FN) causes life-threatening complications, but little is known in septic shock patients with FN. The aim of this study was to investigate the prognostic value of inflammatory markers, including C-reactive protein level, immature granulocyte coun...

Full description

Saved in:
Bibliographic Details
Published in:Shock (Augusta, Ga.) Ga.), 2019-08, Vol.52 (2), p.160-165
Main Authors: Kim, Youn-Jung, Kang, Jihoon, Ryoo, Seung Mok, Ahn, Shin, Huh, Jin Won, Kim, Won Young
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c3566-49839c391821d016c9919b1fd0bcfbaa06b399adc3c0c62ec3bcfa43509698393
cites cdi_FETCH-LOGICAL-c3566-49839c391821d016c9919b1fd0bcfbaa06b399adc3c0c62ec3bcfa43509698393
container_end_page 165
container_issue 2
container_start_page 160
container_title Shock (Augusta, Ga.)
container_volume 52
creator Kim, Youn-Jung
Kang, Jihoon
Ryoo, Seung Mok
Ahn, Shin
Huh, Jin Won
Kim, Won Young
description INTRODUCTION:Chemotherapy-induced febrile neutropenia (FN) causes life-threatening complications, but little is known in septic shock patients with FN. The aim of this study was to investigate the prognostic value of inflammatory markers, including C-reactive protein level, immature granulocyte count, white blood cell (WBC) count, absolute neutrophil count (ANC), neutrophil–lymphocyte ratio (NLR), and platelet–lymphocyte ratio (PLR), in septic shock patients with FN at admission and after granulocyte colony-stimulating factor (G-CSF) administration. METHODS:Data on consecutive adult septic shock patients with FN treated with G-CSF between June 2012 and June 2017 were extracted from a prospectively compiled septic shock registry. Clinical and serial laboratory data at admission and 100 (adjusted odds ratio [aOR], 9.394; 95% CI, 2.821–31.285, P < 0.001) showed sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of 89.4%, 46.2%, 82.9%, and 60.0%, respectively, and APACHE II
doi_str_mv 10.1097/SHK.0000000000001256
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2095542366</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2095542366</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3566-49839c391821d016c9919b1fd0bcfbaa06b399adc3c0c62ec3bcfa43509698393</originalsourceid><addsrcrecordid>eNp9kc1u1DAUhS0EoqXwBgh5ySbFP4lnzG406rQVBUYMiGXkODeNGccOtqMqO96Bp-F1eBI8moIQC-7mXh2d79zFQeg5JeeUyMWr3dWbc_LXUFaJB-iUViUpSEXLh_kmC14wztgJehLjF0JYyeXiMTrhhJbLhaCn6MfWqgQW0s9v3-08jL3XcwL8QSXj8apLEPBlUG6yR33trXcz3iUzTBk07hZvlE4-4FU7GGdiCgfSvcbK4QsV7Iy3wd86H5PR-K0K-xxoHN7BeBB2-d0ebzMCLkX82aQer3sYfOohqHEurl07aWjxBppgLOB3MKXgR3BGPUWPOmUjPLvfZ-jT5uLj-qq4eX95vV7dFJpXQhSlXHKpuaRLRltChZaSyoZ2LWl01yhFRMOlVK3mmmjBQPOsq5JXRIoDys_Qy2PuGPzXCWKqBxM1WKsc-CnWjMiqKhkXIlvLo1UHH2OArh6DGVSYa0rqQ2l1Lq3-t7SMvbj_MDUDtH-g3y1lw_JouPM2NxL3drqDUPegbOr_n_0Ly3CojQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2095542366</pqid></control><display><type>article</type><title>Platelet–lymphocyte Ratio After Granulocyte Colony Stimulating Factor Administration: an Early Prognostic Marker in Septic Shock Patients With Chemotherapy-Induced Febrile Neutropenia</title><source>Freely Accessible Science Journals - check A-Z of ejournals</source><creator>Kim, Youn-Jung ; Kang, Jihoon ; Ryoo, Seung Mok ; Ahn, Shin ; Huh, Jin Won ; Kim, Won Young</creator><creatorcontrib>Kim, Youn-Jung ; Kang, Jihoon ; Ryoo, Seung Mok ; Ahn, Shin ; Huh, Jin Won ; Kim, Won Young</creatorcontrib><description>INTRODUCTION:Chemotherapy-induced febrile neutropenia (FN) causes life-threatening complications, but little is known in septic shock patients with FN. The aim of this study was to investigate the prognostic value of inflammatory markers, including C-reactive protein level, immature granulocyte count, white blood cell (WBC) count, absolute neutrophil count (ANC), neutrophil–lymphocyte ratio (NLR), and platelet–lymphocyte ratio (PLR), in septic shock patients with FN at admission and after granulocyte colony-stimulating factor (G-CSF) administration. METHODS:Data on consecutive adult septic shock patients with FN treated with G-CSF between June 2012 and June 2017 were extracted from a prospectively compiled septic shock registry. Clinical and serial laboratory data at admission and &lt;24 h after G-CSF administration were compared between nonsurvivor and 1-month survivor groups. RESULTS:Of 1,671 septic shock patients, 158 FN patients were treated with G-CSF and 114 (72.2%) survived for 1 month. At admission, no clinical and serial laboratory data were significant to predict survival. After G-CSF administration, PLR and APACHE II were independent predictors for 1-month survival. PLR after administration of G-CSF &gt;100 (adjusted odds ratio [aOR], 9.394; 95% CI, 2.821–31.285, P &lt; 0.001) showed sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of 89.4%, 46.2%, 82.9%, and 60.0%, respectively, and APACHE II &lt;28 (aOR, 6.944; 95% CI, 2.351–20.511, P &lt; 0.001) showed sensitivity, specificity, PPV, and NPV of 86.8%, 63.6%, 86.1%, and 65.1%, respectively. CONCLUSIONS:After G-CSF administration in septic shock patients with chemotherapy-induced FN, PLR may be used as an early prognostic marker for mortality.</description><identifier>ISSN: 1073-2322</identifier><identifier>EISSN: 1540-0514</identifier><identifier>DOI: 10.1097/SHK.0000000000001256</identifier><identifier>PMID: 30148761</identifier><language>eng</language><publisher>United States: by the Shock Society</publisher><ispartof>Shock (Augusta, Ga.), 2019-08, Vol.52 (2), p.160-165</ispartof><rights>2019 by the Shock Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3566-49839c391821d016c9919b1fd0bcfbaa06b399adc3c0c62ec3bcfa43509698393</citedby><cites>FETCH-LOGICAL-c3566-49839c391821d016c9919b1fd0bcfbaa06b399adc3c0c62ec3bcfa43509698393</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30148761$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Youn-Jung</creatorcontrib><creatorcontrib>Kang, Jihoon</creatorcontrib><creatorcontrib>Ryoo, Seung Mok</creatorcontrib><creatorcontrib>Ahn, Shin</creatorcontrib><creatorcontrib>Huh, Jin Won</creatorcontrib><creatorcontrib>Kim, Won Young</creatorcontrib><title>Platelet–lymphocyte Ratio After Granulocyte Colony Stimulating Factor Administration: an Early Prognostic Marker in Septic Shock Patients With Chemotherapy-Induced Febrile Neutropenia</title><title>Shock (Augusta, Ga.)</title><addtitle>Shock</addtitle><description>INTRODUCTION:Chemotherapy-induced febrile neutropenia (FN) causes life-threatening complications, but little is known in septic shock patients with FN. The aim of this study was to investigate the prognostic value of inflammatory markers, including C-reactive protein level, immature granulocyte count, white blood cell (WBC) count, absolute neutrophil count (ANC), neutrophil–lymphocyte ratio (NLR), and platelet–lymphocyte ratio (PLR), in septic shock patients with FN at admission and after granulocyte colony-stimulating factor (G-CSF) administration. METHODS:Data on consecutive adult septic shock patients with FN treated with G-CSF between June 2012 and June 2017 were extracted from a prospectively compiled septic shock registry. Clinical and serial laboratory data at admission and &lt;24 h after G-CSF administration were compared between nonsurvivor and 1-month survivor groups. RESULTS:Of 1,671 septic shock patients, 158 FN patients were treated with G-CSF and 114 (72.2%) survived for 1 month. At admission, no clinical and serial laboratory data were significant to predict survival. After G-CSF administration, PLR and APACHE II were independent predictors for 1-month survival. PLR after administration of G-CSF &gt;100 (adjusted odds ratio [aOR], 9.394; 95% CI, 2.821–31.285, P &lt; 0.001) showed sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of 89.4%, 46.2%, 82.9%, and 60.0%, respectively, and APACHE II &lt;28 (aOR, 6.944; 95% CI, 2.351–20.511, P &lt; 0.001) showed sensitivity, specificity, PPV, and NPV of 86.8%, 63.6%, 86.1%, and 65.1%, respectively. CONCLUSIONS:After G-CSF administration in septic shock patients with chemotherapy-induced FN, PLR may be used as an early prognostic marker for mortality.</description><issn>1073-2322</issn><issn>1540-0514</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9kc1u1DAUhS0EoqXwBgh5ySbFP4lnzG406rQVBUYMiGXkODeNGccOtqMqO96Bp-F1eBI8moIQC-7mXh2d79zFQeg5JeeUyMWr3dWbc_LXUFaJB-iUViUpSEXLh_kmC14wztgJehLjF0JYyeXiMTrhhJbLhaCn6MfWqgQW0s9v3-08jL3XcwL8QSXj8apLEPBlUG6yR33trXcz3iUzTBk07hZvlE4-4FU7GGdiCgfSvcbK4QsV7Iy3wd86H5PR-K0K-xxoHN7BeBB2-d0ebzMCLkX82aQer3sYfOohqHEurl07aWjxBppgLOB3MKXgR3BGPUWPOmUjPLvfZ-jT5uLj-qq4eX95vV7dFJpXQhSlXHKpuaRLRltChZaSyoZ2LWl01yhFRMOlVK3mmmjBQPOsq5JXRIoDys_Qy2PuGPzXCWKqBxM1WKsc-CnWjMiqKhkXIlvLo1UHH2OArh6DGVSYa0rqQ2l1Lq3-t7SMvbj_MDUDtH-g3y1lw_JouPM2NxL3drqDUPegbOr_n_0Ly3CojQ</recordid><startdate>201908</startdate><enddate>201908</enddate><creator>Kim, Youn-Jung</creator><creator>Kang, Jihoon</creator><creator>Ryoo, Seung Mok</creator><creator>Ahn, Shin</creator><creator>Huh, Jin Won</creator><creator>Kim, Won Young</creator><general>by the Shock Society</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201908</creationdate><title>Platelet–lymphocyte Ratio After Granulocyte Colony Stimulating Factor Administration: an Early Prognostic Marker in Septic Shock Patients With Chemotherapy-Induced Febrile Neutropenia</title><author>Kim, Youn-Jung ; Kang, Jihoon ; Ryoo, Seung Mok ; Ahn, Shin ; Huh, Jin Won ; Kim, Won Young</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3566-49839c391821d016c9919b1fd0bcfbaa06b399adc3c0c62ec3bcfa43509698393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Youn-Jung</creatorcontrib><creatorcontrib>Kang, Jihoon</creatorcontrib><creatorcontrib>Ryoo, Seung Mok</creatorcontrib><creatorcontrib>Ahn, Shin</creatorcontrib><creatorcontrib>Huh, Jin Won</creatorcontrib><creatorcontrib>Kim, Won Young</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Shock (Augusta, Ga.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Youn-Jung</au><au>Kang, Jihoon</au><au>Ryoo, Seung Mok</au><au>Ahn, Shin</au><au>Huh, Jin Won</au><au>Kim, Won Young</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Platelet–lymphocyte Ratio After Granulocyte Colony Stimulating Factor Administration: an Early Prognostic Marker in Septic Shock Patients With Chemotherapy-Induced Febrile Neutropenia</atitle><jtitle>Shock (Augusta, Ga.)</jtitle><addtitle>Shock</addtitle><date>2019-08</date><risdate>2019</risdate><volume>52</volume><issue>2</issue><spage>160</spage><epage>165</epage><pages>160-165</pages><issn>1073-2322</issn><eissn>1540-0514</eissn><abstract>INTRODUCTION:Chemotherapy-induced febrile neutropenia (FN) causes life-threatening complications, but little is known in septic shock patients with FN. The aim of this study was to investigate the prognostic value of inflammatory markers, including C-reactive protein level, immature granulocyte count, white blood cell (WBC) count, absolute neutrophil count (ANC), neutrophil–lymphocyte ratio (NLR), and platelet–lymphocyte ratio (PLR), in septic shock patients with FN at admission and after granulocyte colony-stimulating factor (G-CSF) administration. METHODS:Data on consecutive adult septic shock patients with FN treated with G-CSF between June 2012 and June 2017 were extracted from a prospectively compiled septic shock registry. Clinical and serial laboratory data at admission and &lt;24 h after G-CSF administration were compared between nonsurvivor and 1-month survivor groups. RESULTS:Of 1,671 septic shock patients, 158 FN patients were treated with G-CSF and 114 (72.2%) survived for 1 month. At admission, no clinical and serial laboratory data were significant to predict survival. After G-CSF administration, PLR and APACHE II were independent predictors for 1-month survival. PLR after administration of G-CSF &gt;100 (adjusted odds ratio [aOR], 9.394; 95% CI, 2.821–31.285, P &lt; 0.001) showed sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of 89.4%, 46.2%, 82.9%, and 60.0%, respectively, and APACHE II &lt;28 (aOR, 6.944; 95% CI, 2.351–20.511, P &lt; 0.001) showed sensitivity, specificity, PPV, and NPV of 86.8%, 63.6%, 86.1%, and 65.1%, respectively. CONCLUSIONS:After G-CSF administration in septic shock patients with chemotherapy-induced FN, PLR may be used as an early prognostic marker for mortality.</abstract><cop>United States</cop><pub>by the Shock Society</pub><pmid>30148761</pmid><doi>10.1097/SHK.0000000000001256</doi><tpages>6</tpages></addata></record>
fulltext fulltext
identifier ISSN: 1073-2322
ispartof Shock (Augusta, Ga.), 2019-08, Vol.52 (2), p.160-165
issn 1073-2322
1540-0514
language eng
recordid cdi_proquest_miscellaneous_2095542366
source Freely Accessible Science Journals - check A-Z of ejournals
title Platelet–lymphocyte Ratio After Granulocyte Colony Stimulating Factor Administration: an Early Prognostic Marker in Septic Shock Patients With Chemotherapy-Induced Febrile Neutropenia
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-22T18%3A47%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Platelet%E2%80%93lymphocyte%20Ratio%20After%20Granulocyte%20Colony%20Stimulating%20Factor%20Administration:%20an%20Early%20Prognostic%20Marker%20in%20Septic%20Shock%20Patients%20With%20Chemotherapy-Induced%20Febrile%20Neutropenia&rft.jtitle=Shock%20(Augusta,%20Ga.)&rft.au=Kim,%20Youn-Jung&rft.date=2019-08&rft.volume=52&rft.issue=2&rft.spage=160&rft.epage=165&rft.pages=160-165&rft.issn=1073-2322&rft.eissn=1540-0514&rft_id=info:doi/10.1097/SHK.0000000000001256&rft_dat=%3Cproquest_cross%3E2095542366%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c3566-49839c391821d016c9919b1fd0bcfbaa06b399adc3c0c62ec3bcfa43509698393%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2095542366&rft_id=info:pmid/30148761&rfr_iscdi=true