Cellular Immune Response of Adenoidal and Tonsillar Lymphocytes to the P6 Outer Membrane Protein of Non-typeable Haemophilus Influenzae and its Relation to Otitis Media

Cellular immune responses to the P6 outer membrane protein of non-typeable Haemophilus influenzae (NTHi) were determined in vitro by measuring immunoglobulin (Ig) secreting cells and lymphocyte proliferation in adenoidal and tonsillar lymphocytes from 19 children. Preliminary tests showed that P6 di...

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Bibliographic Details
Published in:Acta oto-laryngologica 1999-01, Vol.119 (3), p.377-383
Main Author: Hiroyuki Kodama, Howard Faden, Yasuaki Harabuchi, Akikatsu Kataura, Joel M. Bernstein, Linda Brodsky
Format: Article
Language:English
Subjects:
Acute Disease
Adenoids - immunology
Adenoids - surgery
Antibodies, Bacterial - immunology
Antibody Specificity - immunology
Bacterial Outer Membrane Proteins - immunology
Biological and medical sciences
Cell Movement - physiology
Child
Child, Preschool
Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology
Female
Haemophilus Infections - complications
Haemophilus Infections - immunology
Haemophilus influenzae
Haemophilus Vaccines - immunology
Humans
Male
Medical sciences
Nasopharynx - microbiology
Non tumoral diseases
Otitis Media with Effusion - etiology
Otitis Media with Effusion - immunology
Otorhinolaryngology. Stomatology
Palatine Tonsil - immunology
Palatine Tonsil - surgery
T-Lymphocytes - immunology
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Summary:Cellular immune responses to the P6 outer membrane protein of non-typeable Haemophilus influenzae (NTHi) were determined in vitro by measuring immunoglobulin (Ig) secreting cells and lymphocyte proliferation in adenoidal and tonsillar lymphocytes from 19 children. Preliminary tests showed that P6 did not stimulate naïve cells such as cord blood lymphocytes, but did stimulate sensitized cells in adenoids and tonsils. Cellular proliferation was significantly higher in adenoidal lymphocytes than in tonsillar lymphocytes (median: quadratile of stimulation index=3.7:2.3-5.5 vs. 1.2:1.0-2.1, p
ISSN:0001-6489
1651-2251
DOI:10.1080/00016489950181422