Altered regulation of the T-cell system in patients with CRPS

The aim of this study was to investigate T-cell subsets and immunomodulatory factors in patients with complex regional pain syndrome (CRPS). We found decreased numbers of pro-inflammatory Th17 cells in patients with CRPS as compared to healthy volunteers. The expression of Th17 related RORγT mRNA wa...

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Bibliographic Details
Published in:Inflammation research 2019-01, Vol.68 (1), p.1-6
Main Authors: Heyn, Jens, Azad, Shahnaz C., Luchting, Benjamin
Format: Article
Language:English
Subjects:
Allergology
Biomedical and Life Sciences
Biomedicine
Cell differentiation
Complex regional pain syndrome
Cytokines
Dermatology
Differentiation (biology)
Flow cytometry
Gene expression
Helper cells
Immunology
Immunomodulation
Inflammation
Lymphocytes T
mRNA
Neurology
Pain
Patients
Pharmacology/Toxicology
Rheumatology
Short Communication
Trauma
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Summary:The aim of this study was to investigate T-cell subsets and immunomodulatory factors in patients with complex regional pain syndrome (CRPS). We found decreased numbers of pro-inflammatory Th17 cells in patients with CRPS as compared to healthy volunteers. The expression of Th17 related RORγT mRNA was also significantly decreased. Patients with CRPS showed an increased proportion of CD39 + Tregs. CD39 is a known inhibitor of Th17 cell differentiation. Systemic cytokine levels were almost unchanged in patients with CRPS. These findings suggest that the decrease in Th17 cells in CRPS is regulated by an increase in CD39 + Tregs and that this anti-inflammatory T-cell shift may be a mechanism to control inflammation in CRPS. German clinical trial register Registration Trial DRKS00005954.
ISSN:1023-3830
1420-908X
DOI:10.1007/s00011-018-1182-3