Butyl hydroxytoluene (BHT)-induced oxidative stress: Effects on serum lipids and cardiac energy metabolism in rats

Recent lines of evidences indicate that several pathological conditions, as cardiovascular diseases, are associated with oxidative stress. In order to validate a butylated hydroxytoluene (BHT)-induced experimental model of oxidative stress in the cardiac tissue and serum lipids, 12 Wistar rats were...

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Bibliographic Details
Published in:Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 2006-01, Vol.57 (3), p.221-226
Main Authors: Faine, L.A., Rodrigues, H.G., Galhardi, C.M., Ebaid, G.M.X., Diniz, Y.S., Fernandes, A.A.H., Novelli, E.L.B.
Format: Article
Language:English
Subjects:
Animals
Antioxidant enzymes
Antioxidants - toxicity
Biological and medical sciences
Body Weight
Butylated hydroxytoluene
Butylated Hydroxytoluene - toxicity
Cholesterol
Disease Models, Animal
Dose-Response Relationship, Drug
Energy Metabolism
Heart
Investigative techniques, diagnostic techniques (general aspects)
Lipid Peroxidation
Lipids - blood
Male
Medical sciences
Myocardium
Oxidative Stress
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Rats
Rats, Wistar
Serum lipids
Triacylglycerols
Weight Gain
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Summary:Recent lines of evidences indicate that several pathological conditions, as cardiovascular diseases, are associated with oxidative stress. In order to validate a butylated hydroxytoluene (BHT)-induced experimental model of oxidative stress in the cardiac tissue and serum lipids, 12 Wistar rats were divided into two groups, a control group and the BHT group, which received BHT i.p. twice a week (1500 mg/kg body weight) during 30 days. BHT group presented lower body weight gain and heart weight. BHT induced toxic effects on serum through increased triacylglycerols (TG), VLDL and LDL-cholesterol concentrations. The heart of BHT animals showed alteration of antioxidant defenses and increased concentrations of lipid hydroperoxides, indicating elevated lipoperoxidation. TG concentrations and lactate dehydrogenase activities were elevated in the cardiac muscle of BHT animals. Thus, long-term administration of BHT is capable to induce oxidative and metabolic alterations similarly to some pathological disorders, constituting an efficient experimental model to health scientific research.
ISSN:0940-2993
1618-1433
DOI:10.1016/j.etp.2005.10.001