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Neural Signatures of Semantic and Phonemic Fluency in Young and Old Adults
As we age, our ability to select and to produce words changes, yet we know little about the underlying neural substrate of word-finding difficulties in old adults. This study was designed to elucidate changes in specific frontally mediated retrieval processes involved in word-finding difficulties as...
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| Published in: | Journal of cognitive neuroscience 2009-10, Vol.21 (10), p.2007-2018 |
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| Main Authors: | , , , , , , , |
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| cites | cdi_FETCH-LOGICAL-c664t-d0384b5a0b4d009865ac271475b0bf5b0812f4cd0275300fbb0e5d6d1bcbe1323 |
| container_end_page | 2018 |
| container_issue | 10 |
| container_start_page | 2007 |
| container_title | Journal of cognitive neuroscience |
| container_volume | 21 |
| creator | Meinzer, Marcus Flaisch, Tobias Wilser, Lotte Eulitz, Carsten Rockstroh, Brigitte Conway, Tim Gonzalez-Rothi, Leslie Crosson, Bruce |
| description | As we age, our ability to select and to produce words changes, yet we know little about the underlying neural substrate of word-finding difficulties in old adults. This study was designed to elucidate changes in specific frontally mediated retrieval processes involved in word-finding difficulties associated with advanced age. We implemented two overt verbal (semantic and phonemic) fluency tasks during fMRI and compared brain activity patterns of old and young adults. Performance during the phonemic task was comparable for both age groups and mirrored by strongly left-lateralized (frontal) activity patterns. On the other hand, a significant drop of performance during the semantic task in the older group was accompanied by additional right (inferior and middle) frontal activity, which was negatively correlated with performance. Moreover, the younger group recruited different subportions of the left inferior frontal gyrus for both fluency tasks, whereas the older participants failed to show this distinction. Thus, functional integrity and efficient recruitment of left frontal language areas seems to be critical for successful word retrieval in old age. |
| doi_str_mv | 10.1162/jocn.2009.21219 |
| format | article |
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| ispartof | Journal of cognitive neuroscience, 2009-10, Vol.21 (10), p.2007-2018 |
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| source | ERIC; Linguistics and Language Behavior Abstracts (LLBA); MIT Press Journals |
| subjects | Acoustic Stimulation - methods Adult Age Differences Age Factors Aged Aged, 80 and over Aging - physiology Brain Brain - blood supply Brain - physiology Brain Hemisphere Functions Brain Mapping Cognitive Processes Female Humans Image Processing, Computer-Assisted - methods Information processing Integrity Language Fluency Language Processing Language Tests Lateral Dominance Magnetic Resonance Imaging - methods Male Middle Aged Neuropsychological Tests Neurosciences NMR Nuclear magnetic resonance Older Adults Older people Oxygen - blood Phonemics Phonetics Psychometrics Recall Semantics Statistics as Topic Task Analysis Vocabulary Young Adult Young Adults |
| title | Neural Signatures of Semantic and Phonemic Fluency in Young and Old Adults |
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