Gephyrin, a major postsynaptic protein of GABAergic synapses

γ‐aminobutyric acid type A (GABAA) receptors are located at the majority of inhibitory synapses in the mammalian brain. However, the mechanisms by which GABAA receptor subunits are targeted to, and clustered in, the postsynaptic membrane are poorly understood. Recent studies have demonstrated that g...

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Bibliographic Details
Published in:The European journal of neuroscience 2000-07, Vol.12 (7), p.2205-2210
Main Authors: Sassoè-Pognetto, Marco, Fritschy, Jean-Marc
Format: Article
Language:English
Subjects:
GABAA receptor
glycine receptor
inhibitory synapse
postsynaptic specialization
receptor clustering
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Summary:γ‐aminobutyric acid type A (GABAA) receptors are located at the majority of inhibitory synapses in the mammalian brain. However, the mechanisms by which GABAA receptor subunits are targeted to, and clustered in, the postsynaptic membrane are poorly understood. Recent studies have demonstrated that gephyrin, a protein first identified as a component of the glycine receptor (GlyR) complex, is colocalized with several subtypes of GABAA receptors and is involved in the stabilization of postsynaptic GABAA receptor clusters. Thus, gephyrin functions as a clustering protein for major subtypes of inhibitory ion channel receptors.
ISSN:0953-816X
1460-9568
DOI:10.1046/j.1460-9568.2000.00106.x