Are the therapeutic strategies in anorexia of ageing effective on nutritional status? A systematic review with meta‐analysis

Background Anorexia of ageing (AA) may be considered as a risk factor for frailty and has an important impact on quality of life, morbidity and mortality. Methods A systematic review and a meta‐analysis were performed to summarise the results from several trials on the effectiveness of treatments in...

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Bibliographic Details
Published in:Journal of human nutrition and dietetics 2019-02, Vol.32 (1), p.128-138
Main Authors: Perna, S., Rondanelli, M., Spadaccini, D., Lenzi, A., Donini, L. M., Poggiogalle, E.
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Aging
Aging - pathology
Anorexia
Anorexia - physiopathology
Anorexia - therapy
anorexia of ageing
Appetite loss
Body mass
Body Mass Index
Body size
Body Weight
Confidence intervals
elderly
Energy Intake
Female
Food intake
Geriatric Assessment
Humans
Male
malnutrition
Mental depression
Meta-analysis
Middle Aged
Morbidity
Nutrition Assessment
Nutrition Therapy - methods
Nutritional Status
Olfaction
Quality of Life
Reviews
Risk analysis
Risk factors
Satiety
senile anorexia
Smell
Systematic review
Treatment Outcome
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Summary:Background Anorexia of ageing (AA) may be considered as a risk factor for frailty and has an important impact on quality of life, morbidity and mortality. Methods A systematic review and a meta‐analysis were performed to summarise the results from several trials on the effectiveness of treatments in AA, as associated with depression, sensory impairment of taste and smell, decreased appetite or early satiety, and disability. Eligible studies were required to report baseline and follow‐up values, the mean change (∆‐change) from baseline, and/or the mean difference among intervention groups versus control group, concerning food intake (kcal/daily) and/or nutritional outcomes, such as body weight, body mass index, albumin and Mini Nutritional Assessment. Results The systematic review included 20 papers based on different therapeutic approaches concerning food intake and/or nutritional outcomes. The results of the meta‐analysis indicate that the interventions for AA have an important impact on body weight [+1.59 kg; 95% confidence interval (CI) = 1.48–+1.71 kg; P 
ISSN:0952-3871
1365-277X
DOI:10.1111/jhn.12594