Hair analysis for the biomonitoring of polycyclic aromatic hydrocarbon exposure: comparison with urinary metabolites and DNA adducts in a rat model

Alongside the analysis of urinary metabolites which are traditional biomarkers of polycyclic aromatic hydrocarbons (PAH) exposure, the possibility of detecting PAH as well as their metabolites in hair has also recently been demonstrated. As the concentration of pollutants detected in hair is not imp...

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Bibliographic Details
Published in:Archives of toxicology 2018-10, Vol.92 (10), p.3061-3075
Main Authors: Grova, Nathalie, Hardy, Emilie M., Faÿs, François, Duca, Radu C., Appenzeller, Brice M. R.
Format: Article
Language:English
Subjects:
Adducts
Animals
Benzo(a)pyrene
Biological effects
Biomarkers
Biomedical and Life Sciences
Biomedicine
Biomonitoring
Deoxyribonucleic acid
DNA
DNA adducts
Environmental Health
Exposure
Genetic analysis
Hair
Metabolites
Occupational Medicine/Industrial Medicine
Pharmacology/Toxicology
Pollutants
Polycyclic aromatic hydrocarbons
Pyrene
Toxicokinetics and Metabolism
Urine
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Summary:Alongside the analysis of urinary metabolites which are traditional biomarkers of polycyclic aromatic hydrocarbons (PAH) exposure, the possibility of detecting PAH as well as their metabolites in hair has also recently been demonstrated. As the concentration of pollutants detected in hair is not impacted by short-term variations in exposure as can be observed with urine, it accurately represents an individual’s average level of exposure, which is the most relevant information when investigating possible linkages with biological effects. In the current study, based on a rat model exposed to a mixture of PAHs for a 90-day period, the linkage between the PAH exposure level and the resulting concentration of their metabolites in hair was then investigated. The linkage between exposure levels and the concentrations of OH-PAH in hair collected at the end of the experiment were compared to those obtained using urinary concentration of OH-PAH collected from the same animals. Linear relationship between levels of exposure and the concentration of OH-PAH in the rats’ hair ( R 2 0.722–0.965, p  
ISSN:0340-5761
1432-0738
DOI:10.1007/s00204-018-2298-5