Sleep Quality in Ulcerative Colitis: Associations with Inflammation, Psychological Distress, and Quality of Life

Purpose Treatment of ulcerative colitis (UC), given its chronicity and its associated disruptive and often distressing symptoms, is increasingly focusing on maximizing patient quality of life. Poorer quality of life has been found among patients with poor sleep quality, which is much more common in...

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Bibliographic Details
Published in:International journal of behavioral medicine 2018-10, Vol.25 (5), p.517-525
Main Authors: Hood, Megan M., Wilson, Rebecca, Gorenz, Annika, Jedel, Sharon, Raeisi, Shohreh, Hobfoll, Stevan, Keshavarzian, Ali
Format: Article
Language:English
Subjects:
Adult
Anxiety
Anxiety - psychology
Colitis, Ulcerative - psychology
Colon
Depression - psychology
Family Medicine
Female
General Practice
Health Psychology
Humans
Inflammation
Inflammation - psychology
Inflammatory bowel disease
Inflammatory bowel diseases
Intestine
Male
Medicine
Medicine & Public Health
Mental depression
Middle Aged
Mood
Patients
Perception
Prevalence
Quality of life
Quality of Life - psychology
Sleep
Sleep Wake Disorders - epidemiology
Sleep Wake Disorders - psychology
Stress, Psychological - psychology
Ulcerative colitis
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Summary:Purpose Treatment of ulcerative colitis (UC), given its chronicity and its associated disruptive and often distressing symptoms, is increasingly focusing on maximizing patient quality of life. Poorer quality of life has been found among patients with poor sleep quality, which is much more common in patients with UC than in the general population and may be associated with inflammation and psychological distress. Method Forty-seven patients with UC ( n  = 11 flaring) completed measures of sleep quality, depression, state anxiety, gastrointestinal-related anxiety, perceived stress, and quality of life. Measures of inflammation were also obtained. Results Patients endorsed high rates of poor sleep quality, which was highly correlated with depression and poorer inflammatory bowel disease-related quality of life, but was generally not related to other areas of psychological functioning or inflammation. Sleep quality was significantly independently associated with depression and female gender. Conclusion Poor sleep quality is prevalent in patients with UC and is strongly related to depression, suggesting that sleep and mood are important areas to assess in patients with UC in order to inform tailored treatment to improve quality of life.
ISSN:1070-5503
1532-7558
DOI:10.1007/s12529-018-9745-9