Celiac Disease Autoimmunity

Celiac disease is an autoimmune condition triggered by the ingestion of gluten, the protein fraction of wheat, barley and rye. It is not simply an intestinal disease; it is multifactorial caused by many different genetic factors acting together with non-genetic causes. Similar to other autoimmune di...

Full description

Saved in:
Bibliographic Details
Published in:Archivum Immunologiae et Therapiae Experimentalis 2018-12, Vol.66 (6), p.423-430
Main Authors: López Casado, Miguel Ángel, Lorite, Pedro, Ponce de León, Candelaria, Palomeque, Teresa, Torres, Maria Isabel
Format: Article
Language:English
Subjects:
Animals
Antigens
Autoantibodies
Autoantibodies - metabolism
Autoantigens
Autoantigens - immunology
Autoimmune diseases
Autoimmunity
Biomedical and Life Sciences
Biomedicine
Celiac disease
Celiac Disease - immunology
Disease
Disease Models, Animal
Editorial
Genetic factors
Gluten
Glutens - immunology
Humans
Immune response
Immunology
Intestine
Intestines - pathology
Major histocompatibility complex
Major Histocompatibility Complex - genetics
Pharmacology/Toxicology
Small intestine
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Celiac disease is an autoimmune condition triggered by the ingestion of gluten, the protein fraction of wheat, barley and rye. It is not simply an intestinal disease; it is multifactorial caused by many different genetic factors acting together with non-genetic causes. Similar to other autoimmune diseases, celiac disease is a polygenic disorder for which the major histocompatibility complex locus is the most important genetic factor, and is the result of an immune response to self-antigens leading to tissue destruction and the autoantibodies production. Celiac disease exemplifies how an illness can have autoimmune-like features having to be driven by exogenous antigen and how can be reasonably considered as a model of organ-specific autoimmunity.
ISSN:0004-069X
1661-4917
DOI:10.1007/s00005-018-0520-z