Comparison of microRNAs in the intramuscular adipose tissue from Jinhua and Landrace pigs

MicroRNA (miRNA) is critically involved in lipogenesis occurring in various body parts of humans and animals. In this study, to further investigate the role and distribution of miRNA in porcine intramuscular adipose tissue, small RNAs were extracted from Jinhua and Landrace pigs to identify the expr...

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Bibliographic Details
Published in:Journal of cellular biochemistry 2019-01, Vol.120 (1), p.192-200
Main Authors: Miao, Zhiguo, Wang, Shan, Wang, Yimin, Wei, Panpeng, Khan, Muhammad Akram, Zhang, Jinzhou, Guo, Liping, Liu, Dongyang
Format: Article
Language:English
Subjects:
Adipogenesis
Adipogenesis - genetics
Adipose tissue
Adipose Tissue - metabolism
Animals
Base Sequence
Body Fat Distribution
Body parts
Breeding
Databases, Genetic
Encyclopedias
Gene expression
Gene Library
Genes
Genomes
intramuscular adipose tissue
Jinhua pig
Landrace pig
Lipogenesis
Metabolism
microRNAs (miRNAs)
MicroRNAs - genetics
MicroRNAs - metabolism
miRNA
Muscle, Skeletal - anatomy & histology
Polymerase Chain Reaction
Ribonucleic acid
RNA
Software
Swine
Swine - classification
Tissue Distribution
Transcriptome
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Summary:MicroRNA (miRNA) is critically involved in lipogenesis occurring in various body parts of humans and animals. In this study, to further investigate the role and distribution of miRNA in porcine intramuscular adipose tissue, small RNAs were extracted from Jinhua and Landrace pigs to identify the expression profiles of miRNAs. miRNA expression profiles revealed that 558 miRNAs including 287 known and 271 novel miRNAs were identified, and 220 of them showed differential expression in the pigs. Gene ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis suggested that the target genes of the differentially expressed miRNAs were involved in fatty metabolism. In conclusion, the current study reveals the active participation of miRNAs in the regulation of adipogenesis in the intramuscular adipose tissue of Jinhua and Landrace pigs. The current study focuses on the comparison of microRNAs (miRNAs) from two different pig breeds. The results reveal the participation of miRNAs in the regulation of fat metabolism of Jinhua and Landrace pigs. It implicates the potential function of these miRNAs in the formation of fat in two kinds of pigs and has important significance for porcine breeding industry.
ISSN:0730-2312
1097-4644
DOI:10.1002/jcb.27298