Comparison of Effects between Clopidogrel and Cilostazol on Cerebral Perfusion in Nonsurgical Adult Patients with Symptomatically Ischemic Moyamoya Disease: Subanalysis of a Prospective Cohort

Adult patients with symptomatically ischemic moyamoya disease (MMD) initially undergo medical treatment alone including antiplatelet drugs when symptomatic cerebral hemispheres do not exhibit hemodynamic compromise. The purpose of the present study subanalyzing the same patient cohort used in a prev...

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Bibliographic Details
Published in:Journal of stroke and cerebrovascular diseases 2018-11, Vol.27 (11), p.3373-3379
Main Authors: Chiba, Takayuki, Setta, Kengo, Shimada, Yasuyoshi, Yoshida, Jun, Fujimoto, Kentaro, Tsutsui, Shouta, Yoshida, Kenji, Kobayashi, Masakazu, Kubo, Yoshitaka, Fujiwara, Shunrou, Terasaki, Kazunori, Ogasawara, Kuniaki
Format: Article
Language:English
Subjects:
adult
antiplatelet drug
hemodynamic compromise
Moyamoya disease
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Summary:Adult patients with symptomatically ischemic moyamoya disease (MMD) initially undergo medical treatment alone including antiplatelet drugs when symptomatic cerebral hemispheres do not exhibit hemodynamic compromise. The purpose of the present study subanalyzing the same patient cohort used in a previous study was to determine which antiplatelet drug, clopidogrel or cilostazol, provides better improvement of cerebral perfusion in such patients. All patients without cerebral misery perfusion on 15O gas positron emission tomography (PET) did not undergo revascularization surgery and were treated with medication alone, including antiplatelet therapy. Patients ≥50years and
ISSN:1052-3057
1532-8511
DOI:10.1016/j.jstrokecerebrovasdis.2018.07.041