The role of two-component regulatory system in β-lactam antibiotics resistance

The irrational use of antibiotics in agriculture and in the medical field has led to a variety of pathogenic microorganisms that produce drug resistance and even multidrug resistance. B-lactam is one of the most widely used antibiotics to treat infectious diseases. Resistance to β-lactam resistance...

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Bibliographic Details
Published in:Microbiological research 2018-10, Vol.215, p.126-129
Main Authors: Lingzhi, Li, Haojie, Ge, Dan, Gu, Hongmei, Meng, Yang, Li, Mengdie, Jia, Chengkun, Zheng, Xiaohui, Zhou
Format: Article
Language:English
Subjects:
Antibiotic resistance
B-lactam
Two-component regulatory system
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Summary:The irrational use of antibiotics in agriculture and in the medical field has led to a variety of pathogenic microorganisms that produce drug resistance and even multidrug resistance. B-lactam is one of the most widely used antibiotics to treat infectious diseases. Resistance to β-lactam resistance can be primarily due to the presence β-lactamase, mutation of β-lactam targets and overexpression of efflux pumps. Two-component regulatory systems are composed of histidine kinase and response regulator that regulate gene expression under different environmental conditions. In this review, we summarized the mechanisms by which β-lactam resistance is developed and the role of the two-component regulatory system in β-lactam resistance.
ISSN:0944-5013
1618-0623
DOI:10.1016/j.micres.2018.07.005