Impact of High Respiratory Exchange Ratio During Submaximal Exercise on Adverse Clinical Outcome in Heart Failure

Background: Oxygen uptake (V̇O2) at peak workload and anaerobic threshold (AT) workload are often used for grading heart failure (HF) severity and predicting all-cause mortality. The clinical relevance of respiratory exchange ratio (RER) during exercise, however, is unknown. Methods and Results: We...

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Bibliographic Details
Published in:Circulation Journal 2018/10/25, Vol.82(11), pp.2753-2760
Main Authors: Kakutani, Naoya, Fukushima, Arata, Yokota, Takashi, Katayama, Takashi, Nambu, Hideo, Shirakawa, Ryosuke, Maekawa, Satoshi, Abe, Takahiro, Takada, Shingo, Furihata, Takaaki, Ono, Kota, Okita, Koichi, Kinugawa, Shintaro, Anzai, Toshihisa
Format: Article
Language:English
Subjects:
Adult
Aged
Anaerobic threshold
Cardiopulmonary exercise testing
Disease-Free Survival
Exercise Test
Exercise Therapy
Female
Heart failure
Heart Failure - mortality
Heart Failure - physiopathology
Heart Failure - therapy
Heart Rate
Humans
Kaplan-Meier Estimate
Male
Middle Aged
Respiratory exchange ratio
Respiratory Function Tests
Retrospective Studies
Submaximal exercise
Survival Rate
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Summary:Background: Oxygen uptake (V̇O2) at peak workload and anaerobic threshold (AT) workload are often used for grading heart failure (HF) severity and predicting all-cause mortality. The clinical relevance of respiratory exchange ratio (RER) during exercise, however, is unknown. Methods and Results: We retrospectively studied 295 HF patients (57±15 years, NYHA class I–III) who underwent cardiopulmonary exercise testing. RER was measured at rest; at AT workload; and at peak workload. Peak V̇O2 had an inverse correlation with RER at AT workload (r=−0.256), but not at rest (r=−0.084) or at peak workload (r=0.090). Using median RER at AT workload, we divided the patients into high RER (≥0.97) and low RER (
ISSN:1346-9843
1347-4820
1347-4820
DOI:10.1253/circj.CJ-18-0103