The feasibility of two anthropometric indices to identify metabolic syndrome, insulin resistance and inflammatory factors in obese and overweight adults

• Published in: Nutrition (Burbank, Los Angeles County, Calif.) Los Angeles County, Calif.), 2019-01, Vol.57, p.194-201
• Main Authors: Li, Gang, Wu, Hui-kun, Wu, Xiao-wei, Cao, Zhe, Tu, Yuan-chao, Ma, Yi, Li, Bo-ning, Peng, Qiu-yue, Cheng, Jian, Wu, Bing, Zhou, Zhongyu
• Format: Article
• Language: English
• Subjects: A body shape index; Abdomen; Adult; Adults; Age; Anthropometry; Anthropometry - methods; Area Under Curve; Asian Continental Ancestry Group; Blood pressure; Body Mass Index; Body measurements; Body roundness index; Body weight; C-reactive protein; C-Reactive Protein - metabolism; Cholesterol; Confidence intervals; Cross-Sectional Studies; Diabetes; Diabetes mellitus; Education; Enzymes; Family income; Feasibility Studies; Female; Glucose; Humans; Hypertension; Inflammation; Inflammation - blood; Inflammation - diagnosis; Inflammation - etiology; Inflammatory factors; Insulin; Insulin - blood; Insulin Resistance; Interleukin 6; Interleukin-6 - blood; Lipids; Logistic Models; Male; Metabolic disorders; Metabolic syndrome; Metabolic Syndrome - blood; Metabolic Syndrome - diagnosis; Metabolic Syndrome - etiology; Metabolism; Middle Aged; Mortality; Obesity; Obesity - complications; Obesity - metabolism; Obesity - pathology; Odds Ratio; Overweight; Questionnaires; Regression analysis; Regression coefficients; Resistance factors; Risk Factors; Roundness; Sexes; Shape; Statistical analysis; Tumor Necrosis Factor-alpha - blood; Tumor necrosis factor-TNF; Tumor necrosis factor-α; Waist Circumference; Womens health
• ISSN: 0899-9007; 1873-1244
• DOI: 10.1016/j.nut.2018.05.004

•In an overweight and obese populations, body roundness index and waist circumference were associated significantly with metabolic syndrome (MetS) and insulin resistance (IR).•Body roundness index had the highest odds ratios for IR and waist circumference had the highest odds ratios for MetS in all anthropometric indices.•A body shape index did not exhibit any association between the MetS and IR. A body shape index (ABSI) and body roundness index (BRI) were reported to predict diabetes and hypertension in general population, but their validity was regularly questioned. The aim of this study was to evaluate whether ABSI and BRI are the best anthropometric indices to reflect metabolic syndrome (MetS), insulin resistance (IR), and inflammatory factors in obese and overweight Chinese adults. Cross-sectional data on sociodemographic, lifestyle, anthropometric indices, clinical characteristics, and biochemical measurements were collected for 1442 Chinese obese and overweight adults. Logistic regression analysis examined the associations between anthropometric indices with incidences of MetS and IR in both sexes. Furthermore, the correlation between anthropometric indices and inflammatory factors was assessed. Multivariate regression analysis depicting BRI and waist circumference (WC) were associated significantly with MetS and IR. BRI had the highest odds ratios (ORs) for IR and WC had the highest ORs for MetS in all anthropometric indices. However, ABSI did not exhibit any association between the MetS and IR. The ABSI adjusted regression coefficients (β values) were 0.403 for high-sensitivity C reactive protein, 0.077 for tumor necrosis factor-α, and 0.022 for interleukin-6. BRI and WC were also significantly associated with three inflammatory factors. Comparing the lowest with the highest quintile, BRI had the largest ORs for MetS (OR, 5.778; 95% confidence interval [CI], 2.954–11.303; P < 0.01) and IR (OR, 6.212; 95% CI, 2.912–13.250; P < 0.01). Only BRI and WC, not ABSI, can significantly determine the presence of MetS and IR. BRI showed the optimal capability to identify IR in obese and overweight population.