Tissue-Engineered Odontogenesis

In this study, we have developed a tooth regeneration model derived from mouse tooth germ cells based on tissue engineering. Lower first molars from DDY mice embryos at E 14 were used. Biodegradable Polyglycolate acid (PGA) scaffolds were fabricated, seeded with dissociated the first molars cells, a...

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Bibliographic Details
Published in:Journal of Hard Tissue Biology 2005, Vol.14(2), pp.178-179
Main Authors: Iwatsuki, Shinji, Honda, Masaki J., Harada, Hidemitsu, Ueda, Minoru
Format: Article
Language:English
Subjects:
odontogenesis
tissue-engineering
tooth
tooth germ
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Summary:In this study, we have developed a tooth regeneration model derived from mouse tooth germ cells based on tissue engineering. Lower first molars from DDY mice embryos at E 14 were used. Biodegradable Polyglycolate acid (PGA) scaffolds were fabricated, seeded with dissociated the first molars cells, and implanted into the subcapsular layer of kidney in an adult mouse where they allowed to develop over 3, 5, 7, and 14 days. We present histological analyses characterizing tissue-engineered tooth (TE-tooth). Histological analysis of 14 day implants tissue revealed mineralized enamel and dentin layer were apparent, of the kind of found in normally developing teeth.
ISSN:1341-7649
1880-828X
DOI:10.2485/jhtb.14.178