A pilot study of immunotherapy in dogs with atopic dermatitis using a mannan‐Dermatophagoides farinae allergoid targeting dendritic cells

Background Polymerized allergoids coupled to nonoxidized mannan (PM‐allergoids) are novel allergen preparations used for immunotherapy. Objective To evaluate PM‐allergoids as an alternative immunotherapy for dogs with canine atopic dermatitis (cAD) associated with serological responses to Dermatopha...

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Bibliographic Details
Published in:Veterinary dermatology 2018-10, Vol.29 (5), p.449-e152
Main Authors: González, José‐Luis, Zalve, Vicente, Fernández‐Caldas, Enrique, Cases, Bárbara, Subiza, José‐Luis, Casanovas, Miguel
Format: Article
Language:English
Subjects:
Acarus siro
Allergens
Atopic dermatitis
Dendritic cells
Dermatitis
Dogs
Immunoglobulin E
Immunotherapy
Mannan
Pruritus
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Summary:Background Polymerized allergoids coupled to nonoxidized mannan (PM‐allergoids) are novel allergen preparations used for immunotherapy. Objective To evaluate PM‐allergoids as an alternative immunotherapy for dogs with canine atopic dermatitis (cAD) associated with serological responses to Dermatophagoides farinae allergens. Animals Sixteen dogs with history and clinical signs of cAD; positive on serum allergen specific IgE testing to D. farinae. Twelve dogs were, in addition, positive to Acarus siro and/or Lepidoglyphus destructor. Methods and materials A prospective pilot study with no control group. PM‐allergoids were administered by subcutaneous injection over a 10 month period. A pruritus Visual Analog Scale (pVAS) and medication scores were evaluated. Adverse reactions were recorded. Results The median value of the pVAS of the dogs decreased from 0.6 to 0.2 with a median of 67% improvement over the first three months (P 
ISSN:0959-4493
1365-3164
DOI:10.1111/vde.12679