Co-Administration of Progesterone and Melatonin Attenuates Ischemia-Induced Hippocampal Damage in Rats

Stroke is the second leading reason for death worldwide and is one of the fundamental causes of long-term disabilities. The aim of this investigation was to assess the impact of combined administration progesterone (PROG) and melatonin (MEL) on stroke complications. Male Wistar rats (9–10 weeks) wei...

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Bibliographic Details
Published in:Journal of molecular neuroscience 2018-10, Vol.66 (2), p.251-260
Main Authors: Hedayatpour, Azim, Shiasi, Maryam, Famitafreshi, Hamidreza, Abolhassani, Farid, Ebrahimnia, Parisa, Mokhtari, Tahmineh, Hassanzaeh, Gholamreza, Karimian, Morteza, Nazparvar, Bashir, Marefati, Narges, Tarzjani, Masoomeh Dehghan
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Arteries
Biomedical and Life Sciences
Biomedicine
Brain Ischemia - drug therapy
Carotid arteries
Carotid artery
Cell Biology
Complications
Disabilities
Drug Therapy, Combination
Gene expression
Hippocampus
Hippocampus - drug effects
Hippocampus - pathology
Ischemia
Learning
Male
Maze Learning
Melatonin
Melatonin - administration & dosage
Melatonin - pharmacology
Melatonin - therapeutic use
Memory tasks
Neurochemistry
Neurology
Neuroprotective Agents - administration & dosage
Neuroprotective Agents - pharmacology
Neuroprotective Agents - therapeutic use
Neurosciences
Progesterone
Progesterone - administration & dosage
Progesterone - pharmacology
Progesterone - therapeutic use
Proteins
Proteomics
Pyramidal cells
Pyramidal Cells - drug effects
Pyramidal Cells - pathology
Rats
Rats, Wistar
Rodents
Spatial analysis
Spatial memory
Stroke
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Summary:Stroke is the second leading reason for death worldwide and is one of the fundamental causes of long-term disabilities. The aim of this investigation was to assess the impact of combined administration progesterone (PROG) and melatonin (MEL) on stroke complications. Male Wistar rats (9–10 weeks) weighing 250–300 g were used as a part of this examination. They were randomly separated into eight groups (nine rats for every group). Common carotid arteries on the two sides clamped (BCCAO model) with non-traumatic clips for 20 min. At that point, the rats were treated with 8 mg/kg PROG, 10 mg/kg MEL, and vehicles (sesamoid and normal saline). Morris water maze testing was performed following 2 weeks. At that point, the rats were euthanized, and histological examination was directed. The outcome demonstrated that utilization of PROG and MEL in treatment groups essentially increases the quantity of pyramidal cells and enhances spatial memory compared to non-treatment groups ( p  
ISSN:0895-8696
1559-1166
DOI:10.1007/s12031-018-1163-6