Docetaxel-Loaded Hyaluronic Acid–Cathepsin B‑Cleavable-Peptide–Gold Nanoparticles for the Treatment of Cancer

Gold nanoparticles are commonly used for medical applications such as drug delivery and as therapeutic and diagnostic materials because of their unique properties. In this study, we prepared docetaxel (DTX)-loaded hyaluronic acid–cleavable-peptide–gold nanoparticles for the treatment of cancer by se...

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Bibliographic Details
Published in:Molecular pharmaceutics 2018-10, Vol.15 (10), p.4668-4676
Main Authors: Gotov, Oyuntuya, Battogtokh, Gantumur, Ko, Young Tag
Format: Article
Language:English
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Summary:Gold nanoparticles are commonly used for medical applications such as drug delivery and as therapeutic and diagnostic materials because of their unique properties. In this study, we prepared docetaxel (DTX)-loaded hyaluronic acid–cleavable-peptide–gold nanoparticles for the treatment of cancer by selectively delivering DTX into the tumor and, thus, enhancing the therapeutic effect of DTX; further, we determined synergistic effects of the nanoparticles using laser treatment. The DTX-loaded hyaluronic acid–cleavable-peptide–gold nanoparticles prepared in this study had an average size of 75 nm and negative surface charge. The nanoparticles revealed greater cytotoxicity and higher tumor suppression efficacy in tumor models than free DTX under near-infrared laser irradiation. Therefore, the nanoparticle formulation prepared in this study could be utilized for targeted drug delivery and in combination with other cancer therapies.
ISSN:1543-8384
1543-8392
DOI:10.1021/acs.molpharmaceut.8b00640