Risk of endometrial cancer in asymptomatic postmenopausal patients with thickened endometrium: data from the FAME-Endo study: an observational register study

Purpose To evaluate the risk for endometrial cancer (EC) in a large series of asymptomatic patients with thickened endometrium at ultrasound examination based on previously published data of a theoretical cohort. Methods In a prospective register study, a total of 1024 women with thickened endometri...

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Bibliographic Details
Published in:Archives of gynecology and obstetrics 2018-10, Vol.298 (4), p.813-820
Main Authors: Hefler, Lukas, Lafleur, Judith, Kickmaier, Sonja, Leipold, Heinz, Siebenhofer, Carmen, Tringler, Barbara, Schauer, Christian, Ciresa-König, Alexandra, Reinthaller, Alexander
Format: Article
Language:English
Subjects:
Aged
Endocrinology
Endometrial cancer
Endometrial Neoplasms - etiology
Endometrial Neoplasms - pathology
Endometrium - pathology
Female
Gynecologic Oncology
Gynecology
Hormone replacement therapy
Human Genetics
Humans
Hyperplasia
Logistic Models
Medicine
Medicine & Public Health
Middle Aged
Obstetrics/Perinatology/Midwifery
Postmenopause
Prospective Studies
Registries
Ultrasonic imaging
Ultrasonography
Vagina - diagnostic imaging
Vagina - pathology
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Summary:Purpose To evaluate the risk for endometrial cancer (EC) in a large series of asymptomatic patients with thickened endometrium at ultrasound examination based on previously published data of a theoretical cohort. Methods In a prospective register study, a total of 1024 women with thickened endometrium in ultrasound examination undergoing histological diagnosis by dilation, hysteroscopy and curettage were evaluated. 124 patients were excluded due to current medication with tamoxifen and/or presence of HNPCC leaving 900 patients for further analysis. Results Mean [standard deviation (SD)] age of patients was 65.6 (8.6) years. Mean (SD) endometrial thickness was 11.9 (5.8) mm. 32 and 6 cases of EC and complex endometrial hyperplasia with atypia were found, respectively. In the univariate analysis, a statistically significant association between endometrial thickness, current use of antihypertensive medication, number of deliveries, and the presence of endometrial fluid in preoperative vaginal ultrasound ( p   11 mm endometrial thickness to discriminate between “normal” and “pathological”. The data regarding “risk for endometrial cancer” can be used for counseling affected women.
ISSN:0932-0067
1432-0711
DOI:10.1007/s00404-018-4885-3