Veno-occlusive disease after high-dose busulfan–melphalan in neuroblastoma

• Published in: Bone marrow transplantation (Basingstoke) 2020-03, Vol.55 (3), p.531-537
• Main Authors: Schechter, Tal, Perez-Albuerne, Evelio, Lin, Tiffany F., Irwin, Meredith S., Essa, Mohammed, Desai, Ami V., Frangoul, Haydar, Yanik, Gregory, Dupuis, L. Lee, Jacobsohn, David, Kletzel, Morris, Ranalli, Mark, Soni, Sandeep, Seif, Alix E., Grupp, Stephan, Dvorak, Christopher C.
• Format: Article
• Language: English
• Subjects: 692/499; 692/699/67; Autografts; Busulfan; Care and treatment; Cell Biology; Chemotherapy; Children; Complications and side effects; Development and progression; Evaluation; Health risks; Hematology; Internal Medicine; Intravenous administration; Liver diseases; Medicine; Medicine & Public Health; Melphalan; Neuroblastoma; Neutrophils; Oncology; Parameter modification; Pediatric research; Pharmacokinetics; Public Health; Risk factors; Serum levels; Steady state; Stem cell transplantation; Stem Cells; Survival; Toxicity; Transplantation; Veno-occlusive disease
• ISSN: 0268-3369; 1476-5365
• DOI: 10.1038/s41409-018-0298-y

Survival for high-risk neuroblastoma patients is still suboptimal. Although stem cell transplantation (SCT) is used, there is no consensus as to which conditioning regimen has the greatest efficacy and fewest toxicities. We assessed the incidence of and risk for hepatic veno-occlusive disease (VOD) for neuroblastoma patients who underwent autologous SCT with busulfan and melphalan (BuMel) at eight centers following Children’s Oncology Group (COG)-based induction chemotherapy. Data regarding the patients, SCT characteristics, busulfan steady-state concentrations, incidence of VOD, and survival were evaluated. VOD was defined using the modified Seattle criteria. Possible factors associated with VOD (age, busulfan-pharmacokinetic parameters, history of hepatic dysfunction, and day of neutrophil engraftment) were evaluated. Seventy five patients were included and 23 children (31%) developed VOD at a median of 19 days after SCT (range 14–27 days). VOD was the cause of death in 4 patients (5%). In a multivariable analysis, young age (OR 1.7 (95% CI: 1.16–2.56; p = 0.012)) and early day of neutrophil engraftment (OR 1.4 (95% CI: 1.08–2.14; p = 0.041) were associated with the development of VOD. Initial or cumulative busulfan steady-state concentration were not associated with VOD. We found that despite the use of intravenous busulfan with adjusted serum levels, the incidence of VOD remains high in pediatric neuroblastoma patients.