Decoration of Cisplatin on 2D Metal–Organic Frameworks for Enhanced Anticancer Effects through Highly Increased Reactive Oxygen Species Generation

Herein, a biocompatible 2D metal–organic frameworks (Cu-TCPP­(Fe)) based on TCPP­(M) (TCPP = tetrakis (4-carboxyphenyl) porphyrin, M = Fe) and copper ion were synthesized as a novel drug carrier. Sequentially, the cisplatin was loaded on the merge of carboxyl-rich Cu-TCPP­(Fe) through forming favora...

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Bibliographic Details
Published in:ACS applied materials & interfaces 2018-09, Vol.10 (37), p.30930-30935
Main Authors: Li, Yaojia, Gao, Zhiguo, Chen, Fanghui, You, Chaoqun, Wu, Hongshuai, Sun, Kai, An, Peijing, Cheng, Kaiwu, Sun, Chen, Zhu, Xiaoli, Sun, Baiwang
Format: Article
Language:English
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Summary:Herein, a biocompatible 2D metal–organic frameworks (Cu-TCPP­(Fe)) based on TCPP­(M) (TCPP = tetrakis (4-carboxyphenyl) porphyrin, M = Fe) and copper ion were synthesized as a novel drug carrier. Sequentially, the cisplatin was loaded on the merge of carboxyl-rich Cu-TCPP­(Fe) through forming favorable carboxyl–drug interactions. The prepared Pt/Cu-TCPP­(Fe) showed highly enhanced cytotoxicity than that of free cisplatin in human pulmonary carcinoma A549 cells, whereas inverse inhibitory effects were observed in human normal BEAS-2B cells. Further, the mechanism of action about the desirable results was also elaborated. Our study highlighted the potential synergies between the nanocarrier and the anticancer drugs.
ISSN:1944-8244
1944-8252
DOI:10.1021/acsami.8b12800