Bioabsorbable device to prepare subcutaneous pockets for islet transplantation

Small invasive transplantation of islets and long maintenance of the islet graft without immunosuppression has been studied for the treatment of type 1 diabetes. Clinically, subcutaneous pockets surrounding vascular-rich tissue are prepared for islet transplantation using a device made of the materi...

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Bibliographic Details
Published in:Journal of biomedical materials research. Part B, Applied biomaterials Applied biomaterials, 2019-05, Vol.107 (4), p.1107-1112
Main Authors: Kuwabara, Rei, Iwata, Hiroo
Format: Article
Language:English
Subjects:
Biomedical materials
Diabetes
Diabetes mellitus
Diabetes mellitus (insulin dependent)
Fibroblast growth factor 2
Gelatin
Glucose
Immunosuppression
Implantation
Islet cells
Materials research
Materials science
Pancreatic islet transplantation
Sheets
Sodium
Sodium hyaluronate
Transplantation
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Summary:Small invasive transplantation of islets and long maintenance of the islet graft without immunosuppression has been studied for the treatment of type 1 diabetes. Clinically, subcutaneous pockets surrounding vascular-rich tissue are prepared for islet transplantation using a device made of the materials. Here, gelatin sheets were implanted into two dorsal subcutaneous sites in diabetic ACI rats, and a mixture of bFGF and sodium hyaluronate solution was injected around the gelatin sheets. A total of 1500 islets isolated from F344 rats were transplanted into each of the pockets 7 days after injection of the bFGF mixture. Nine of 10 diabetic ACI rats with allogeneic islet graft demonstrated long-term normoglycemia without administration of immunosuppressant. Gelatin sheets almost disappeared 67 days after implantation. Thus, subcutaneous immune-tolerant sites can be prepared using gelatin sheets and a sodium hyaluronate-bFGF mixture. Allogeneic islets transplanted into the sites can survive and control blood glucose levels for a long period, even without immunosuppression. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 1107-1112, 2019.
ISSN:1552-4973
1552-4981
DOI:10.1002/jbm.b.34203