Treatment of experimentally induced bovine respiratory disease in young calves with a single administration of a combination of florfenicol and meloxicam

This study was designed to evaluate the efficacy of a new florfenicol/meloxicam combination (FMC) in calves with bovine respiratory disease. A total of 90 young calves were challenged via intratracheal deposition of 108 colony-forming units of Mannheimia haemolytica. Data for 84 calves demonstrating...

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Published in:Veterinary record 2018-11, Vol.183 (17), p.535-535
Main Authors: Achard, Damien, Caruso-Vares, Agathe, Collin, Jean-François, McKelvie, Joanne, Reddick, David, Ramage, Cliff
Format: Article
Language:English
Subjects:
Animals
Antibiotics
Antimicrobial agents
Bacteria
bovine respiratory disease
Cattle
Fever
florfenicol
inflammation
meloxicam
Pathogens
Respiratory diseases
treatment
Veterinary medicine
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container_issue 17
container_start_page 535
container_title Veterinary record
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creator Achard, Damien
Caruso-Vares, Agathe
Collin, Jean-François
McKelvie, Joanne
Reddick, David
Ramage, Cliff
description This study was designed to evaluate the efficacy of a new florfenicol/meloxicam combination (FMC) in calves with bovine respiratory disease. A total of 90 young calves were challenged via intratracheal deposition of 108 colony-forming units of Mannheimia haemolytica. Data for 84 calves demonstrating a rectal temperature (RT) above 39.5°C and a combined total clinical score (TCS) greater than or equal to 3 were included. Calves were then randomly allocated to one of the three study groups (FMC; florfenicol/flunixin combination (FFC); or saline) and promptly treated. RT and TCS of calves treated with an FMC or FFC were consistently lower than RT and TCS of calves belonging to the control group (P
doi_str_mv 10.1136/vr.104795
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A total of 90 young calves were challenged via intratracheal deposition of 108 colony-forming units of Mannheimia haemolytica. Data for 84 calves demonstrating a rectal temperature (RT) above 39.5°C and a combined total clinical score (TCS) greater than or equal to 3 were included. Calves were then randomly allocated to one of the three study groups (FMC; florfenicol/flunixin combination (FFC); or saline) and promptly treated. RT and TCS of calves treated with an FMC or FFC were consistently lower than RT and TCS of calves belonging to the control group (P&lt;0.001). Moreover, at the end of the study, a high clinical cure rate was observed in calves treated with FMC (100 per cent) or FFC (96.6 per cent) whereas cure was limited for calves receiving saline (29.6 per cent). Interestingly, calves treated with FMC were cured without relapse more rapidly compared with calves treated with FFC (HR=1.76, P&lt;0.05) and with a lower percentage of clinical relapse due to fever (P=0.05). 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source Wiley-Blackwell Read & Publish Collection
subjects Animals
Antibiotics
Antimicrobial agents
Bacteria
bovine respiratory disease
Cattle
Fever
florfenicol
inflammation
meloxicam
Pathogens
Respiratory diseases
treatment
Veterinary medicine
title Treatment of experimentally induced bovine respiratory disease in young calves with a single administration of a combination of florfenicol and meloxicam
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