Inflammatory myopathies after allogeneic stem cell transplantation

ABSTRACT Introduction,: Graft‐versus‐host disease (GVHD) is a recognized complication of allogeneic stem cell transplantation (allo‐SCT) and may affect muscle. We investigated the incidence and subtypes of inflammatory myopathy (IM) in South Australian recipients of allo‐SCT. Methods: Recipients of...

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Published in:Muscle & nerve 2018-12, Vol.58 (6), p.790-795
Main Authors: New‐Tolley, Julia, Smith, Caroline, Koszyca, Barbara, Otto, Sophia, Maundrell, Adam, Bardy, Peter, Hiwase, Devendra, Yong, Agnes S. M., Lewis, Ian, Limaye, Vidya
Format: Article
Language:English
Subjects:
Antibodies
Biopsy
Creatine
Creatine kinase
Dermatomyositis
Graft versus host disease
Graft-versus-host reaction
Incidence
Inflammation
Inflammatory diseases
inflammatory myopathy
Melanoma
Muscles
Musculoskeletal diseases
Myopathy
myositis
Patients
Proteins
stem cell transplant
Stem cell transplantation
Stem cells
Transplantation
weakness
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Summary:ABSTRACT Introduction,: Graft‐versus‐host disease (GVHD) is a recognized complication of allogeneic stem cell transplantation (allo‐SCT) and may affect muscle. We investigated the incidence and subtypes of inflammatory myopathy (IM) in South Australian recipients of allo‐SCT. Methods: Recipients of allo‐SCT from 2004 to 2014 at the Royal Adelaide Hospital were identified. Records were reviewed to identify patients with weakness, creatine kinase (CK) elevation, and muscle biopsy confirming IM. Results: Weakness was present in 32 of 224 patients who received allo‐SCT patients reviewed, and CK was raised in 7 of 20 patients with weakness. Six patients developed biopsy‐confirmed IM; 3 patients had chronic GVHD‐related myopathy, 2 had necrotizing myopathy, and 1 had dermatomyositis (DM) associated with anti–melanoma differentiation associated protein 5 (MDA5) antibodies. The incidence of IM was calculated to be 2 cases per thousand annually. Discussion: Among recipients of allo‐SCT, weakness is common, and the incidence of IM is increased. Histopathological diagnoses are varied, and we report findings of necrotizing myopathy and anti‐MDA5‐associated DM. Muscle Nerve 58:790–795, 2018
ISSN:0148-639X
1097-4598
DOI:10.1002/mus.26341