The roles of microphthalmia-associated transcription factor and pigmentation in melanoma

•The role of MITF and its targets in melanoma is reviewed.•The role of pigmentation in melanoma is discussed.•Regulation of MITF is reviewed. MITF and pigmentation play important roles in both normal melanocyte and transformed melanoma cell biology. MITF is regulated by many pathways and it also reg...

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Bibliographic Details
Published in:Archives of biochemistry and biophysics 2014-12, Vol.563, p.28-34
Main Authors: Hsiao, Jennifer J., Fisher, David E.
Format: Article
Language:English
Subjects:
Animals
Carcinogenesis
Cell Cycle
Cell Movement
Cell Survival
Cell Transformation, Neoplastic - genetics
Cell Transformation, Neoplastic - metabolism
environmental factors
Humans
Melanins - metabolism
Melanocyte
melanocytes
Melanocytes - metabolism
Melanocytes - pathology
Melanoma
Melanoma - etiology
Melanoma - metabolism
Melanoma - pathology
Microphthalmia-Associated Transcription Factor - genetics
Microphthalmia-Associated Transcription Factor - metabolism
MITF
Neoplasm Invasiveness
Oxidative Stress
Pigmentation
Pigmentation - genetics
Pigmentation - physiology
Skin Neoplasms - etiology
Skin Neoplasms - metabolism
Skin Neoplasms - pathology
transcription factors
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Summary:•The role of MITF and its targets in melanoma is reviewed.•The role of pigmentation in melanoma is discussed.•Regulation of MITF is reviewed. MITF and pigmentation play important roles in both normal melanocyte and transformed melanoma cell biology. MITF is regulated by many pathways and it also regulates many targets, some of which are still being discovered and functionally validated. MITF is involved in a wide range of processes in melanocytes, including pigment synthesis and lineage survival. Pigmentation itself plays an important role as the interface between genetic and environmental factors that contribute to melanoma.
ISSN:0003-9861
1096-0384
DOI:10.1016/j.abb.2014.07.019