Dose-Response Model for Listeria monocytogenes-Induced Stillbirths in Nonhuman Primates

A dose-response model using rhesus monkeys as a surrogate for pregnant women indicates that oral exposure to 10⁷ CFU of Listeria monocytogenes results in about 50% stillbirths. Ten of 33 pregnant rhesus monkeys exposed orally to a single dose of 10² to 10¹⁰ CFU of L. monocytogenes had stillbirths. A...

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Bibliographic Details
Published in:Infection and Immunity 2008-02, Vol.76 (2), p.726-731
Main Authors: Smith, Mary Alice, Takeuchi, Kazue, Anderson, Gary, Ware, Glenn O, McClure, Harold M, Raybourne, Richard B, Mytle, Nutan, Doyle, Michael P
Format: Article
Language:English
Subjects:
Animals
Bacterial Infections
Bacteriology
Biological and medical sciences
Feces - microbiology
Female
Fetus - microbiology
Fundamental and applied biological sciences. Psychology
Lethal Dose 50
Listeria monocytogenes
Listeria monocytogenes - isolation & purification
Listeriosis - complications
Macaca mulatta
Microbiology
Miscellaneous
Placenta - microbiology
Pregnancy
Pregnancy Complications, Infectious
Primates
Stillbirth
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Summary:A dose-response model using rhesus monkeys as a surrogate for pregnant women indicates that oral exposure to 10⁷ CFU of Listeria monocytogenes results in about 50% stillbirths. Ten of 33 pregnant rhesus monkeys exposed orally to a single dose of 10² to 10¹⁰ CFU of L. monocytogenes had stillbirths. A log-logistic model predicts a dose affecting 50% of animals at 10⁷ CFU, comparable to an estimated 10⁶ CFU based on an outbreak among pregnant women but much less than the extrapolated estimate (10¹³ CFU) from the FDA-U.S. Department of Agriculture-CDC risk assessment using an exponential curve based on mouse data. Exposure and etiology of the disease are the same in humans and primates but not in mice. This information will aid in risk assessment, assist policy makers, and provide a model for mechanistic studies of L. monocytogenes-induced stillbirths.
ISSN:0019-9567
1098-5522
DOI:10.1128/IAI.01366-06