Multiparametric imaging-based differentiation of lymphoma and glioblastoma: using T1-perfusion, diffusion, and susceptibility-weighted MRI

To compare the diagnostic performance of T1 perfusion magnetic resonance imaging (MRI), diffusion-weighted imaging (DWI), and susceptibility-weighted imaging (SWI) for differentiating primary central nervous system lymphoma (PCNSL) and glioblastoma (GBM). This retrospective study comprised a cohort...

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Bibliographic Details
Published in:Clinical radiology 2018-11, Vol.73 (11), p.986.e7-986.e15
Main Authors: Saini, J., Kumar Gupta, P., Awasthi, A., Pandey, C.M., Singh, A., Patir, R., Ahlawat, S., Sadashiva, N., Mahadevan, A., Kumar Gupta, R.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Brain - diagnostic imaging
Brain - pathology
Brain Neoplasms - diagnostic imaging
Brain Neoplasms - pathology
Diagnosis, Differential
Diffusion Magnetic Resonance Imaging - methods
Glioblastoma - diagnostic imaging
Glioblastoma - pathology
Humans
Lymphoma - diagnostic imaging
Lymphoma - pathology
Male
Middle Aged
Neuroimaging - methods
Retrospective Studies
Young Adult
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Summary:To compare the diagnostic performance of T1 perfusion magnetic resonance imaging (MRI), diffusion-weighted imaging (DWI), and susceptibility-weighted imaging (SWI) for differentiating primary central nervous system lymphoma (PCNSL) and glioblastoma (GBM). This retrospective study comprised a cohort of 70 patients with glioblastoma and 30 patients with PCNSL. T1 perfusion MRI-derived rCBV_corr (leakage corrected relative cerebral blood volume), apparent diffusion coefficient (ADC) derived from DWI, and intratumoural susceptibility signals intensity (ITSS) measured on SWI were evaluated in these 100 patients. The Mann–Whitney U-test was used for pairwise comparison between groups. The diagnostic performance for differentiating PCNSL from glioblastoma was evaluated by using univariate and multivariable logistic regression analyses and receiver operating characteristic (ROC) analysis. Minimum ADC, maximum rCBVs_corr, kep (back flux exchange rate), and ITSS scores were significantly lower in patients with PCNSL than in those with glioblastoma (p
ISSN:0009-9260
1365-229X
DOI:10.1016/j.crad.2018.07.107