Resistance training in young men induces muscle transcriptome-wide changes associated with muscle structure and metabolism refining the response to exercise-induced stress

• Published in: European journal of applied physiology 2018-12, Vol.118 (12), p.2607-2616
• Main Authors: Damas, Felipe, Ugrinowitsch, Carlos, Libardi, Cleiton A., Jannig, Paulo R., Hector, Amy J., McGlory, Chris, Lixandrão, Manoel E., Vechin, Felipe C., Montenegro, Horacio, Tricoli, Valmor, Roschel, Hamilton, Phillips, Stuart M.
• Format: Article
• Language: English
• Subjects: Adult; Antioxidants; Biomedical and Life Sciences; Biomedicine; Body mass; Cytoskeleton; DNA microarrays; Energy metabolism; Extracellular matrix; Gene expression; Heat shock proteins; Human Physiology; Humans; Male; Metabolism; Muscle contraction; Muscle, Skeletal - anatomy & histology; Muscle, Skeletal - metabolism; Muscle, Skeletal - physiology; Occupational Medicine/Industrial Medicine; Original Article; Oxidative metabolism; Physical training; Protein turnover; Resistance Training; Sports Medicine; Strength training; Stress, Physiological; Transcriptome
• ISSN: 1439-6319; 1439-6327
• DOI: 10.1007/s00421-018-3984-y

Background Gene expression is an important process underpinning the acute and chronic adaptive response to resistance exercise (RE) training. Purpose To investigate the effect of training status on vastus lateralis muscle global transcriptome at rest and following acute RE. Methods Muscle biopsies of nine young men (age: 26(2) years; body mass: 69(9) kg; height 172(6) cm) who undertook RE training for 10 weeks were collected pre and 24 h post-RE in the untrained (W1) and trained (W10) states and analysed using microarray. Tests of differential expression were conducted for rested and after RE contrasts in both training states. To control for false discovery rate (FDR), multiple testing correction was performed at a cut-off of FDR