Lichen planus and diabetes mellitus: Systematic review and meta‐analysis

Objective The aim of this study was to perform a systematic review and meta‐analysis answering the following questions: (a) "What is the prevalence and risk of oral lichen planus among patients with diabetes mellitus?" and (b) "What is the prevalence and risk of diabetes mellitus amon...

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Bibliographic Details
Published in:Oral diseases 2019-07, Vol.25 (5), p.1253-1264
Main Authors: Otero Rey, Eva María, Yáñez‐Busto, Anabel, Rosa Henriques, Inés Filipa, López‐López, José, Blanco‐Carrión, Andrés
Format: Article
Language:English
Subjects:
Dentistry
Diabetes
Diabetes Complications
Diabetes mellitus
Diabetes Mellitus - epidemiology
epidemiologic studies
Humans
Inhibitor drugs
Lichen planus
Lichen Planus, Oral - complications
Lichen Planus, Oral - epidemiology
Lichen Planus, Oral - etiology
Meta-analysis
Morbidity
Mucosa
Prevalence
risk
Systematic review
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Summary:Objective The aim of this study was to perform a systematic review and meta‐analysis answering the following questions: (a) "What is the prevalence and risk of oral lichen planus among patients with diabetes mellitus?" and (b) "What is the prevalence and risk of diabetes mellitus among patients with oral lichen planus?". Material and methods A bibliographic search was conducted in PubMed/Medline and Scopus database from 1966 to March 2018, using the following terms: “Lichen planus” AND “Diabetes mellitus” AND “Prevalence” AND “Oral mucosal lesions”. Results Twenty‐two studies were included in this review. Twelve studies assessed the prevalence of diabetes mellitus among patients with lichen planus. The prevalence reported ranges from 1.6% to 37.7% with a relative risk of 2.432. Ten studies assessed the prevalence of lichen planus among patients with diabetes mellitus which showed a prevalence of lichen planus ranging from 0.5% to 6.1% with a relative risk of 1.4. Conclusions Contradictory results were found when analyzing the relationship between lichen planus and diabetes mellitus. Diverse factors should be considered when studying this association for a correct interpretation of results. Diabetes mellitus has high prevalence and morbidity, which is why new case–control studies are needed to further investigate this association.
ISSN:1354-523X
1601-0825
DOI:10.1111/odi.12977