Dyslipidemias in clinical practice

Most dyslipidemic conditions have been linked to an increased risk of cardiovascular disease. Over the past few years major advances have been made regarding the genetic and metabolic basis of dyslipidemias. Detailed characterization of the genetic basis of familial lipid disorders and knowledge con...

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Bibliographic Details
Published in:Clinica chimica acta 2018-12, Vol.487, p.117-125
Main Authors: Castro Cabezas, Manuel, Burggraaf, Benjamin, Klop, Boudewijn
Format: Article
Language:English
Subjects:
Cardiovascular Diseases - drug therapy
Cardiovascular Diseases - genetics
Cardiovascular Diseases - metabolism
Dyslipidemias - drug therapy
Dyslipidemias - genetics
Dyslipidemias - metabolism
Humans
hypercholesterolemia
hyperlipidemia
Hypolipidemic Agents - therapeutic use
lipid disorder
Lipids - antagonists & inhibitors
Lipoprotein
treatment
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Summary:Most dyslipidemic conditions have been linked to an increased risk of cardiovascular disease. Over the past few years major advances have been made regarding the genetic and metabolic basis of dyslipidemias. Detailed characterization of the genetic basis of familial lipid disorders and knowledge concerning the effects of environmental factors on the expression of dyslipidemias have increased substantially, contributing to a better diagnosis in individual patients. In addition to these developments, therapeutic options to lower cholesterol levels in clinical practice have expanded even further in patients with familial hypercholesterolemia and in subjects with cardiovascular disease. Finally, promising upcoming therapeutic lipid lowering strategies will be reviewed. All these advances will be discussed in relation to current clinical practice with special focus on common lipid disorders including familial dyslipidemias. •Advances have been made regarding the genetic and metabolic basis of dyslipidemias.•The expression of dyslipidemias depends on genetic and environmental factors.•The first step in clinical care in dyslipidemias is establishing the diagnosis.•Therapeutic options to lower cholesterol levels have expanded even further.
ISSN:0009-8981
1873-3492
DOI:10.1016/j.cca.2018.09.010