A Novel Strategy in Prevention and Delay of Type I Diabetes Mellitus (T1DM) Onset by Autoimmunization

With better understanding of T-cell receptor structure and antigen presentation by MHC molecules, we attempted to prevent the disease by inhibiting the initiation of a pathologic immune response instead of intervening at the effector phase.

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2008-03, Vol.121 (3), p.792-792
Main Authors: Lin, M.S, Wong, C, Bertera, S, Pignelli, J, Tse, H, Pietroppaolo, M, Milton, M, He, L, Chang, Y, Zhang, Y, Lakomy, R, Chang, J, Trucco, M
Format: Article
Language:English
Subjects:
Allergy and Immunology
Diabetes
Immune system
Pancreas
Rodents
Online Access:Get full text
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Description
Summary:With better understanding of T-cell receptor structure and antigen presentation by MHC molecules, we attempted to prevent the disease by inhibiting the initiation of a pathologic immune response instead of intervening at the effector phase.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2008.01.043