Effect of Ribose Conformation on RNA Cleavage via Internal Transesterification

RNA cleavage via internal transesterification is a fundamental reaction involved in RNA processing and metabolism, and the regulation thereof. Herein, the influence of ribose conformation on this reaction was investigated with conformationally constrained ribonucleotides. RNA cleavage rates were fou...

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Bibliographic Details
Published in:Journal of the American Chemical Society 2018-09, Vol.140 (38), p.11893-11897
Main Authors: Guo, Fengmin, Yue, Zekun, Trajkovski, Marko, Zhou, Xiaoping, Cao, Dong, Li, Qiang, Wang, Baifan, Wen, Xin, Plavec, Janez, Peng, Qian, Xi, Zhen, Zhou, Chuanzheng
Format: Article
Language:English
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Summary:RNA cleavage via internal transesterification is a fundamental reaction involved in RNA processing and metabolism, and the regulation thereof. Herein, the influence of ribose conformation on this reaction was investigated with conformationally constrained ribonucleotides. RNA cleavage rates were found to decrease in the order South-constrained ribonucleotide > native ribonucleotide ≫ North-constrained counterpart, indicating that the ribose conformation plays an important role in modulating RNA cleavage via internal transesterification.
ISSN:0002-7863
1520-5126
DOI:10.1021/jacs.8b06313