Protection of DNA from gamma-radiation induced strand breaks by Epicatechin

Epicatechin (EC), a polyphenolic antioxidant compound found in tea, apples and chocolate offered protection to DNA against ionizing radiation induced damages. Under in vitro conditions of radiation exposure, plasmid pBR322 DNA was protected by EC in a concentration dependent manner. The dose modifyi...

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Bibliographic Details
Published in:Mutation research. Genetic toxicology and environmental mutagenesis 2008-01, Vol.650 (1), p.48-54
Main Authors: Nair, Cherupally Krishnan Krishnan, Salvi, Veena Prakash
Format: Article
Language:English
Subjects:
Biological and medical sciences
Comet assay
DNA strand-breaks
Epicatechin
Fundamental and applied biological sciences. Psychology
Genetics of eukaryotes. Biological and molecular evolution
Medical sciences
Radiation exposure
Radiation protection
Radioprotector
Toxicology
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Summary:Epicatechin (EC), a polyphenolic antioxidant compound found in tea, apples and chocolate offered protection to DNA against ionizing radiation induced damages. Under in vitro conditions of radiation exposure, plasmid pBR322 DNA was protected by EC in a concentration dependent manner. The dose modifying factor for 0.2 mM EC for 50% protection of the plasmid DNA was found to be 6.0. EC when administered to mice 1 h prior to exposure to 4 Gy gamma-radiation protected cellular DNA against radiation-induced strand breaks in peripheral blood leukocytes, as revealed in alkaline comet assay studies. Thus, EC was found to protect DNA from gamma-radiation indiced strand breaks under in vitro as well as in vivo conditions of radiation exposure.
ISSN:1383-5718
1879-3592
DOI:10.1016/j.mrgentox.2007.10.001