Reexamination of respiration-impairing effect of bikaverin on isolated mitochondria

Kovac et al (1) have shown that bikaverin uncouples oxidative phosphorylation of mitochondria at 20µg/ml (52 nmol/ml) in the reaction system without magnesium (Mg(2+)). In the present study, the effects of bikaverin on mitochondrial reactions were reexamined in detail at various concentrations both...

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Bibliographic Details
Published in:Mycotoxin research 1998-03, Vol.14 (1), p.19-27
Main Authors: Suzuki, T, Kitagawa, A, Kawai, K, Hamasaki, T
Format: Article
Language:English
Subjects:
Electron transport
Energy transfer
Inner membranes
Low concentrations
Magnesium
Membrane permeability
Mitochondria
Mitochondrial DNA
Oxidative phosphorylation
Phosphorylation
Respiration
Rodents
Submitochondrial particles
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Summary:Kovac et al (1) have shown that bikaverin uncouples oxidative phosphorylation of mitochondria at 20µg/ml (52 nmol/ml) in the reaction system without magnesium (Mg(2+)). In the present study, the effects of bikaverin on mitochondrial reactions were reexamined in detail at various concentrations both in the reaction systems with and without magnesium, using isolated rat liver mitochondria and submitochondrial particles (SMP) to characterize its mode of actions to mitochondrial respiration at low concentrations (
ISSN:0178-7888
1867-1632
DOI:10.1007/bf02945089