Receptor imaging of pediatric tumors: clinical practice and new developments

Pediatric cancers often have specific molecular fingerprints making them primary candidates for the development of targeted imaging techniques. Tumor-targeted tracers have the potential to substantially advance the sensitivity and specificity of imaging techniques by improving tumor detection and ch...

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Bibliographic Details
Published in:Pediatric radiology 2008-11, Vol.38 (11), p.1154-1161
Main Authors: Daldrup-Link, Heike E., Hawkins, Randall A., Meier, Reinhard, Goldsby, Robert E., Artemov, Dmitri
Format: Article
Language:English
Subjects:
Antigens, Neoplasm - metabolism
Child
Contrast Media - pharmacokinetics
Humans
Imaging
Magnetic Resonance Imaging - trends
Medicine
Medicine & Public Health
Neoplasms - diagnosis
Neoplasms - diagnostic imaging
Neoplasms - metabolism
Neovascularization, Pathologic - diagnosis
Neovascularization, Pathologic - diagnostic imaging
Neuroradiology
Nuclear Medicine
Oncology
Pediatrics
Radiology
Radionuclide Imaging - trends
Radiopharmaceuticals
Receptors, Cell Surface - metabolism
Review
Ultrasound
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Summary:Pediatric cancers often have specific molecular fingerprints making them primary candidates for the development of targeted imaging techniques. Tumor-targeted tracers have the potential to substantially advance the sensitivity and specificity of imaging techniques by improving tumor detection and characterization. This article reviews various approaches to target tumors via specific tumor antigens, tumor cell surface receptors and specific surface receptors of the endothelial cells of the tumor vessels. These new applied molecular imaging techniques are expected to improve our knowledge of the biology of pediatric cancers and, ultimately, to help in the development of tailored diagnoses and therapies, which may ultimately lead to better individual long-term outcomes.
ISSN:0301-0449
1432-1998
DOI:10.1007/s00247-008-0878-x