Non-healing Skin Ulcers Secondary to Calciphylaxis with Candida tropicalis Fungemia in an End-stage Renal Disease Patient

Calciphylaxis is an uncommon necrotizing skin condition characterized by excessive calcification of soft tissue and small arteries, leading to ischemic ulceration of the skin. It mainly affects patients with chronic renal failure and often leads to fatal consequences. Chronic renal failure, hyperpar...

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Bibliographic Details
Published in:Hong Kong journal of nephrology 2009-10, Vol.11 (2), p.66-69
Main Authors: Shaheen, Mazen, Hammoud, Dalia, Patel, Dimpi, Le, Lisa, Abdallah, Mohammad, Karrowni, Wassef, Amanambu, Chimezie
Format: Article
Language:English
Subjects:
Acinetobacter baumannii
calciphylaxis
Candida tropicalis
end-stage renal disease
Enterococcus
fungemia
skin ulcers
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Summary:Calciphylaxis is an uncommon necrotizing skin condition characterized by excessive calcification of soft tissue and small arteries, leading to ischemic ulceration of the skin. It mainly affects patients with chronic renal failure and often leads to fatal consequences. Chronic renal failure, hyperparathyroidism, hypercalcemia, and hyper-phosphatemia often trigger the precipitation of calcium-phosphate crystals in the arterioles of the dermis and soft tissues, leading to ischemia and skin ulcerations. The diagnosis of calciphylaxis is mainly clinical and skin biopsy is infrequently done because of the risk of poor healing and secondary infections. Despite aggressive treatment regimens, mortality is high. Here, we report the case of a 44-year-old female end-stage renal disease patient with multiple non-healing skin ulcers secondary to calciphylaxis complicated with refractory infections including Candida tropicalis fungemia, vancomycin-resistant enterococcus and Acinetobacter baumannii wound infections.
ISSN:1561-5413
1876-4371
DOI:10.1016/S1561-5413(09)60245-3