A study of in vivo antihypertensive properties of enzymatic hydrolysate from chicken leg bone protein

ABSTRACT Numerous attempts have been made to develop angiotensin I converting enzyme (ACE) inhibitors from various sources of food protein. Generally chicken leg bones are discarded after industrial chicken meat processing without any substantial benefit. In previous studies, chicken leg bone protei...

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Published in:Animal science journal 2008-10, Vol.79 (5), p.614-619
Main Authors: CHENG, Fu-Yuan, WAN, Tien-Chun, LIU, Yu-Tse, LAI, Kung-Ming, LIN, Liang-Chuan, SAKATA, Ryoichi
Format: Article
Language:English
Subjects:
ACE inhibitors
animal by-product
Animal sciences
antihypertension
Bones
chicken bones
hydrolysis
Hypertension
Meat industry
Poultry
Proteins
Rodents
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cited_by cdi_FETCH-LOGICAL-c5271-19e434fc98b837c453c1bf633bb130ffacbcca3e835b3a50737bf50db5d6e8073
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container_end_page 619
container_issue 5
container_start_page 614
container_title Animal science journal
container_volume 79
creator CHENG, Fu-Yuan
WAN, Tien-Chun
LIU, Yu-Tse
LAI, Kung-Ming
LIN, Liang-Chuan
SAKATA, Ryoichi
description ABSTRACT Numerous attempts have been made to develop angiotensin I converting enzyme (ACE) inhibitors from various sources of food protein. Generally chicken leg bones are discarded after industrial chicken meat processing without any substantial benefit. In previous studies, chicken leg bone proteins were hydrolyzed by various enzymes and the results demonstrated that Alcalase hydrolysates have considerable ACE inhibiting activities. In this study, the best ACE inhibitory hydrolysate (A4) (which was derived from chicken leg bone protein by Alcalase after 4 h incubation) was orally administrated (50 mg/kg bw) in spontaneously hypertensive rats (SHRs) to investigate its antihypertensive effects. After oral administration of A4, a maximal reduction activity of about 26 mmHg was found at 4 h and maintained to 8 h. Moreover, SHRs treated with A4 (50 mg/kg bw/day) for eight weeks exhibited a reduction in systolic blood pressure, which is as significant as the effects of Captopril (P 
doi_str_mv 10.1111/j.1740-0929.2008.00571.x
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source Wiley-Blackwell Read & Publish Collection
subjects ACE inhibitors
animal by-product
Animal sciences
antihypertension
Bones
chicken bones
hydrolysis
Hypertension
Meat industry
Poultry
Proteins
Rodents
title A study of in vivo antihypertensive properties of enzymatic hydrolysate from chicken leg bone protein
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