Synthesis of water-degradable silica nanoparticles from carbamate-containing bridged silsesquioxane precursor

Silica nanoparticles (SNPs) are attractive for the delivery of drugs and as imaging agents due to their ease of synthesis and scale up, robust structure, and controllable size and composition. Degradability is one important factor that limits biomedical applications of SNPs. With this in mind, we de...

Full description

Saved in:
Bibliographic Details
Published in:RSC advances 2018-01, Vol.8 (9), p.4914-492
Main Authors: Gao, Zhe, Hadipour Moghaddam, Seyyed Pouya, Ghandehari, Hamidreza, Zharov, Ilya
Format: Article
Language:English
Subjects:
Biomedical materials
Chemistry
Degradation
Drug delivery systems
Electron microscopy
Nanoparticles
Precursors
Robust control
Silicon dioxide
Sorbitol
Synthesis
Tetraethyl orthosilicate
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Silica nanoparticles (SNPs) are attractive for the delivery of drugs and as imaging agents due to their ease of synthesis and scale up, robust structure, and controllable size and composition. Degradability is one important factor that limits biomedical applications of SNPs. With this in mind, we designed, prepared and characterized novel hydrolysable organosilica nanoparticles (ICPTES-sorbitol SNPs). These particles were prepared by co-condensation of tetraethoxysilane with a bridged sorbitol-based silsesquioxane precursor containing carbamate linkages. The non-porous spherical ICPTES-sorbitol SNPs became porous after they were placed in an aqueous environment as a result of the hydrolysis of carbamate bonds and were completely degraded upon prolonged exposure to water. The rate of degradation depended on the pH of the solution, with nanoparticles degrading slower at pH 2 than at pH 4 or pH 7. The degradation was demonstrated by transmission electron microscopy, nitrogen desorption analysis and solution analytical techniques such as ICP-MS and molybdenum blue assay, which was also used to follow the dissolution of ICPTES-sorbitol SNPs. We prepared novel water hydrolysable organosilica nanoparticles by co-condensation of tetraethoxysilane with a bridged sorbitol-based silsesquioxane precursor containing carbamate linkages.
ISSN:2046-2069
2046-2069
DOI:10.1039/c7ra12377a