Malignant brain tumors in patients with glutaric aciduria type I

Three young patients with glutaric aciduria type I (age 6–23 years) of different ethnic origins, treated for their metabolic disease since early childhood, presented with malignant central nervous system tumors. We recommend continuing clinical follow-up, including monitoring of neurological manifes...

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Bibliographic Details
Published in:Molecular genetics and metabolism 2018-11, Vol.125 (3), p.276-280
Main Authors: Serrano Russi, A., Donoghue, S., Boneh, A., Manara, R., Burlina, A.B., Burlina, A.P.
Format: Article
Language:English
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Summary:Three young patients with glutaric aciduria type I (age 6–23 years) of different ethnic origins, treated for their metabolic disease since early childhood, presented with malignant central nervous system tumors. We recommend continuing clinical follow-up, including monitoring of neurological manifestations and neuroradiological findings, in all patients with glutaric aciduria type I beyond early childhood, especially if adherence to diet is poor or the treatment was not started neonatally.
ISSN:1096-7192
1096-7206
DOI:10.1016/j.ymgme.2018.08.006