Systematic review of pre-clinical chronic myeloid leukaemia

Background Studies of a provisional entity pre-clinical chronic myeloid leukaemia (CML), which precedes chronic phase (CP) without leucocytosis or blood/marrow feature of CML CP, has been increasing. Objective To perform a systematic review of pre-clinical CML and analysis the data relevant to disea...

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Bibliographic Details
Published in:International journal of hematology 2018-11, Vol.108 (5), p.465-484
Main Authors: Kuan, Jew Win, Su, Anselm Ting, Leong, Chooi Fun, Osato, Motomi, Sashida, Goro
Format: Article
Language:English
Subjects:
Blood
Bone Marrow - pathology
Chronic myeloid leukemia
Data processing
Disease Progression
Hematology
Humans
Leukemia
Leukemia, Myelogenous, Chronic, BCR-ABL Positive - diagnosis
Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics
Leukemia, Myelogenous, Chronic, BCR-ABL Positive - therapy
Leukemia, Myeloid, Chronic-Phase
Leukocytes (eosinophilic)
Leukocytosis - pathology
Medicine
Medicine & Public Health
Oncology
Philadelphia chromosome
Review Article
Reviews
Systematic review
Treatment Outcome
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Summary:Background Studies of a provisional entity pre-clinical chronic myeloid leukaemia (CML), which precedes chronic phase (CP) without leucocytosis or blood/marrow feature of CML CP, has been increasing. Objective To perform a systematic review of pre-clinical CML and analysis the data relevant to disease progression to CML CP. Method We performed a literature search on 16 July 2017 using EBSCOhost Research Databases interface and Western Pacific Region Index Medicus. Two authors selected the studies, extracted the data and evaluated the quality of studies using an 8-item tool, independently. The outcomes were percentage of Philadelphia chromosome in the number of metaphases examined (Ph%), correlation between Ph% and blood count and time progress to CML. Result Our initial search returned 4770 studies. A total of 10 studies with a total 17 subjects were included. The lowest Ph%, which eventually progresses to CML, was 10%. Absolute basophil count seemed to correlate better with Ph% compared to total white cell and absolute eosinophil count. The time from the first documented pre-clinical CML to CML ranged from 12 to 48 months. The overall quality of the included studies was average. Conclusion This is the first systematic review on pre-clinical CML. This entity requires additional large-scale studies.
ISSN:0925-5710
1865-3774
DOI:10.1007/s12185-018-2528-x