Genetic Control of Immune Response in Carriers of the 8.1 Ancestral Haplotype

:  Ancestral haplotype (AH) 8.1(HLA‐A1, Cw7, B8, TNFAB*a2b3, TNFN*S, C2*C, Bf*s, C4A*Q0, C4B*1, DRB1*0301, DRB3*0101, DQA1*0501, DQB1*0201) seems to be associated with susceptibility to autoimmune diseases. Different mechanisms are probably involved in increasing autoimmunity, such as unbalanced cyt...

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Published in:Annals of the New York Academy of Sciences 2007-09, Vol.1110 (1), p.151-158
Main Authors: CANDORE, GIUSEPPINA, CAMPAGNA, ANNA MARIA, CUPPARI, IRENE, CARLO, DANIELE DI, MINEO, CLAUDIA, CARUSO, CALOGERO
Format: Article
Language:English
Subjects:
AH 8.1
autoimmune diseases
DR3
HLA-B8
HLA‐B8,DR3
IgG subclasses
immune response
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Summary::  Ancestral haplotype (AH) 8.1(HLA‐A1, Cw7, B8, TNFAB*a2b3, TNFN*S, C2*C, Bf*s, C4A*Q0, C4B*1, DRB1*0301, DRB3*0101, DQA1*0501, DQB1*0201) seems to be associated with susceptibility to autoimmune diseases. Different mechanisms are probably involved in increasing autoimmunity, such as unbalanced cytokine production and the lack of C4A protein. So AH 8.1 modifies immune response in many ways. In this study we demonstrate that IgG2 serum levels were significantly lower in 8.1 AH carriers than in 8.1 AH non‐carriers. On the contrary, as regards IgG1, IgG3, IgG4 serum levels, no significant differences were observed between the two groups. In AH 8.1 carriers low IgG2 levels might take to slower clearance of the infectious agent and hence to a lasting presence of it. The persistence of infectious antigens could determine an increased production of autoantibodies with a higher risk of cross‐reactions.
ISSN:0077-8923
1749-6632
1930-6547
DOI:10.1196/annals.1423.017