Long-term oral polyamine intake increases blood polyamine concentrations

Although the intracellular de novo synthesis of the polyamines decreases with age, there is no similar trend in blood polyamine levels, but rather there is wide individual variability. We hypothesized that dietary polyamines attenuate a decrease in blood polyamine levels with age and augment the pre...

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Published in:Journal of Nutritional Science and Vitaminology 2009, Vol.55(4), pp.361-366
Main Authors: Soda, K.(Jichi Medical Univ., Saitama (Japan)), Kano, Y, Sakuragi, M, Takao, K, Lefor, A, Konishi, F
Format: Article
Language:English
Subjects:
ALIMENTOS
Biological and medical sciences
ESPERMINA
Feeding. Feeding behavior
FISIOLOGIA HUMANA
food
FOODS
Fundamental and applied biological sciences. Psychology
human
HUMAN PHYSIOLOGY
MICE
PHYSIOLOGIE HUMAINE
POLIAMINAS
POLYAMINE
POLYAMINES
PRODUIT ALIMENTAIRE
RATON
SOURIS
SPERMINE
Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Summary:Although the intracellular de novo synthesis of the polyamines decreases with age, there is no similar trend in blood polyamine levels, but rather there is wide individual variability. We hypothesized that dietary polyamines attenuate a decrease in blood polyamine levels with age and augment the previously observed individual variability. The effect of a polyamine rich diet, in both mice and humans, on blood polyamine concentrations was examined in this study. Jc1:ICR male mice were fed test diets containing 3 different polyamine concentrations. Healthy human male volunteers added 50 to 100 g of the polyamine-rich fermented soybean product, natto, to their daily intake. After 26 wk, the mean blood spermine concentration in mice receiving the test diet with high polyamine concentrations was 10.1+-2.4 micro mol/L, while the mean concentrations found in mice fed with a diet with normal or low polyamine concentrations were 5.2+-0.9 and 4.7+-0.5 micro mol/L, respectively (p0.05). A mean daily intake of 66.4+-3.7 g (range
ISSN:0301-4800
1881-7742
DOI:10.3177/jnsv.55.361