Combined dapsone and clofazimine intoxication

We report clinical findings and pharmacokinetic data regarding a combined dapsone and clofazimine intoxica tion in a man, who ingested 50 tablets of dapsone (100 mg), 20 capsules of clofazimine (100 mg) and two tablets of rifampicin (600 mg). Oral administration of activated charcoal (50 grams) and...

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Bibliographic Details
Published in:Human & experimental toxicology 1996-08, Vol.15 (8), p.625-628
Main Authors: Hoetelmans, Rmw, Otten, Jmmb, Koks, Chw, Soesan, M., Beijnen, JH
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Charcoal
Clofazimine - blood
Clofazimine - poisoning
Dapsone - analogs & derivatives
Dapsone - blood
Dapsone - poisoning
Drug Overdose
Drug toxicity and drugs side effects treatment
Gastric Lavage
Humans
Leprostatic Agents - blood
Leprostatic Agents - poisoning
Male
Medical sciences
Methemoglobinemia - blood
Methemoglobinemia - chemically induced
Methemoglobinemia - drug therapy
Methylene Blue - therapeutic use
Pharmacology. Drug treatments
Rifampin - poisoning
Suicide, Attempted
Sulfates - therapeutic use
Toxicity: blood
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Summary:We report clinical findings and pharmacokinetic data regarding a combined dapsone and clofazimine intoxica tion in a man, who ingested 50 tablets of dapsone (100 mg), 20 capsules of clofazimine (100 mg) and two tablets of rifampicin (600 mg). Oral administration of activated charcoal (50 grams) and sodium sulphate (20 grams) after gastric lavage resulted in an elimination half-life in plasma of 11.1 and 10.8 h for dapsone and its main metabolite, monoacetyldapsone, respectively. A rapid initial decrease of the plasma concentration of clofazi mine was observed after gastric lavage and administration of activated charcoal and sodium sulphate. 15 h after this treatment, clofazimine plasma levels remained relatively constant. Dapsone-induced methaemoglobinaemia (48% at admission) was treated successfully with methylene blue.
ISSN:0960-3271
1477-0903
DOI:10.1177/096032719601500805