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Combined dapsone and clofazimine intoxication
We report clinical findings and pharmacokinetic data regarding a combined dapsone and clofazimine intoxica tion in a man, who ingested 50 tablets of dapsone (100 mg), 20 capsules of clofazimine (100 mg) and two tablets of rifampicin (600 mg). Oral administration of activated charcoal (50 grams) and...
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| Published in: | Human & experimental toxicology 1996-08, Vol.15 (8), p.625-628 |
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| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c398t-60d3ae904869fcd9fa5ca3c3c1f411f4f98332e7e7d48cfdcc53a24eeeca02363 |
| container_end_page | 628 |
| container_issue | 8 |
| container_start_page | 625 |
| container_title | Human & experimental toxicology |
| container_volume | 15 |
| creator | Hoetelmans, Rmw Otten, Jmmb Koks, Chw Soesan, M. Beijnen, JH |
| description | We report clinical findings and pharmacokinetic data regarding a combined dapsone and clofazimine intoxica tion in a man, who ingested 50 tablets of dapsone (100 mg), 20 capsules of clofazimine (100 mg) and two tablets of rifampicin (600 mg). Oral administration of activated charcoal (50 grams) and sodium sulphate (20 grams) after gastric lavage resulted in an elimination half-life in plasma of 11.1 and 10.8 h for dapsone and its main metabolite, monoacetyldapsone, respectively. A rapid initial decrease of the plasma concentration of clofazi mine was observed after gastric lavage and administration of activated charcoal and sodium sulphate. 15 h after this treatment, clofazimine plasma levels remained relatively constant. Dapsone-induced methaemoglobinaemia (48% at admission) was treated successfully with methylene blue. |
| doi_str_mv | 10.1177/096032719601500805 |
| format | article |
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Oral administration of activated charcoal (50 grams) and sodium sulphate (20 grams) after gastric lavage resulted in an elimination half-life in plasma of 11.1 and 10.8 h for dapsone and its main metabolite, monoacetyldapsone, respectively. A rapid initial decrease of the plasma concentration of clofazi mine was observed after gastric lavage and administration of activated charcoal and sodium sulphate. 15 h after this treatment, clofazimine plasma levels remained relatively constant. Dapsone-induced methaemoglobinaemia (48% at admission) was treated successfully with methylene blue.</description><identifier>ISSN: 0960-3271</identifier><identifier>EISSN: 1477-0903</identifier><identifier>DOI: 10.1177/096032719601500805</identifier><identifier>PMID: 8863056</identifier><language>eng</language><publisher>Thousand Oaks, CA: SAGE Publications</publisher><subject>Adult ; Biological and medical sciences ; Charcoal ; Clofazimine - blood ; Clofazimine - poisoning ; Dapsone - analogs & derivatives ; Dapsone - blood ; Dapsone - poisoning ; Drug Overdose ; Drug toxicity and drugs side effects treatment ; Gastric Lavage ; Humans ; Leprostatic Agents - blood ; Leprostatic Agents - poisoning ; Male ; Medical sciences ; Methemoglobinemia - blood ; Methemoglobinemia - chemically induced ; Methemoglobinemia - drug therapy ; Methylene Blue - therapeutic use ; Pharmacology. Drug treatments ; Rifampin - poisoning ; Suicide, Attempted ; Sulfates - therapeutic use ; Toxicity: blood</subject><ispartof>Human & experimental toxicology, 1996-08, Vol.15 (8), p.625-628</ispartof><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c398t-60d3ae904869fcd9fa5ca3c3c1f411f4f98332e7e7d48cfdcc53a24eeeca02363</citedby><cites>FETCH-LOGICAL-c398t-60d3ae904869fcd9fa5ca3c3c1f411f4f98332e7e7d48cfdcc53a24eeeca02363</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/096032719601500805$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/096032719601500805$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>309,310,314,780,784,789,790,21845,23930,23931,25140,27924,27925,45082,45470</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3205279$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8863056$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hoetelmans, Rmw</creatorcontrib><creatorcontrib>Otten, Jmmb</creatorcontrib><creatorcontrib>Koks, Chw</creatorcontrib><creatorcontrib>Soesan, M.</creatorcontrib><creatorcontrib>Beijnen, JH</creatorcontrib><title>Combined dapsone and clofazimine intoxication</title><title>Human & experimental toxicology</title><addtitle>Hum Exp Toxicol</addtitle><description>We report clinical findings and pharmacokinetic data regarding a combined dapsone and clofazimine intoxica tion in a man, who ingested 50 tablets of dapsone (100 mg), 20 capsules of clofazimine (100 mg) and two tablets of rifampicin (600 mg). Oral administration of activated charcoal (50 grams) and sodium sulphate (20 grams) after gastric lavage resulted in an elimination half-life in plasma of 11.1 and 10.8 h for dapsone and its main metabolite, monoacetyldapsone, respectively. A rapid initial decrease of the plasma concentration of clofazi mine was observed after gastric lavage and administration of activated charcoal and sodium sulphate. 15 h after this treatment, clofazimine plasma levels remained relatively constant. Dapsone-induced methaemoglobinaemia (48% at admission) was treated successfully with methylene blue.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Charcoal</subject><subject>Clofazimine - blood</subject><subject>Clofazimine - poisoning</subject><subject>Dapsone - analogs & derivatives</subject><subject>Dapsone - blood</subject><subject>Dapsone - poisoning</subject><subject>Drug Overdose</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Gastric Lavage</subject><subject>Humans</subject><subject>Leprostatic Agents - blood</subject><subject>Leprostatic Agents - poisoning</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Methemoglobinemia - blood</subject><subject>Methemoglobinemia - chemically induced</subject><subject>Methemoglobinemia - drug therapy</subject><subject>Methylene Blue - therapeutic use</subject><subject>Pharmacology. Drug treatments</subject><subject>Rifampin - poisoning</subject><subject>Suicide, Attempted</subject><subject>Sulfates - therapeutic use</subject><subject>Toxicity: blood</subject><issn>0960-3271</issn><issn>1477-0903</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><recordid>eNp9kEtLxDAUhYMo4zj6BwShC3FX5yZpkmYpgy8YcKPrkslDMrTJ2LSg_nozTHEjuLicxfnOuXAQusRwi7EQS5AcKBE4C2YANbAjNMeVECVIoMdovgfKPXGKzlLaAgCXDM_QrK45BcbnqFzFbuODNYVRuxSDLVQwhW6jU9--y0bhwxA_vVaDj-EcnTjVJnsx6QK9Pdy_rp7K9cvj8-puXWoq66HkYKiyEqqaS6eNdIppRTXV2FU4n5M1pcQKK0xVa2e0ZlSRylqrFRDK6QLdHHp3ffwYbRqazidt21YFG8fUEAycs4pmkBxA3ceUeuuaXe871X81GJr9Rs3fjXLoamofN501v5FplOxfT75KWrWuV0H79ItRAowImbHlAUvq3TbbOPYhb_Lf4x_FensQ</recordid><startdate>19960801</startdate><enddate>19960801</enddate><creator>Hoetelmans, Rmw</creator><creator>Otten, Jmmb</creator><creator>Koks, Chw</creator><creator>Soesan, M.</creator><creator>Beijnen, JH</creator><general>SAGE Publications</general><general>Arnold</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>19960801</creationdate><title>Combined dapsone and clofazimine intoxication</title><author>Hoetelmans, Rmw ; Otten, Jmmb ; Koks, Chw ; Soesan, M. ; Beijnen, JH</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c398t-60d3ae904869fcd9fa5ca3c3c1f411f4f98332e7e7d48cfdcc53a24eeeca02363</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Charcoal</topic><topic>Clofazimine - blood</topic><topic>Clofazimine - poisoning</topic><topic>Dapsone - analogs & derivatives</topic><topic>Dapsone - blood</topic><topic>Dapsone - poisoning</topic><topic>Drug Overdose</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Gastric Lavage</topic><topic>Humans</topic><topic>Leprostatic Agents - blood</topic><topic>Leprostatic Agents - poisoning</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Methemoglobinemia - blood</topic><topic>Methemoglobinemia - chemically induced</topic><topic>Methemoglobinemia - drug therapy</topic><topic>Methylene Blue - therapeutic use</topic><topic>Pharmacology. Drug treatments</topic><topic>Rifampin - poisoning</topic><topic>Suicide, Attempted</topic><topic>Sulfates - therapeutic use</topic><topic>Toxicity: blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hoetelmans, Rmw</creatorcontrib><creatorcontrib>Otten, Jmmb</creatorcontrib><creatorcontrib>Koks, Chw</creatorcontrib><creatorcontrib>Soesan, M.</creatorcontrib><creatorcontrib>Beijnen, JH</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Human & experimental toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hoetelmans, Rmw</au><au>Otten, Jmmb</au><au>Koks, Chw</au><au>Soesan, M.</au><au>Beijnen, JH</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Combined dapsone and clofazimine intoxication</atitle><jtitle>Human & experimental toxicology</jtitle><addtitle>Hum Exp Toxicol</addtitle><date>1996-08-01</date><risdate>1996</risdate><volume>15</volume><issue>8</issue><spage>625</spage><epage>628</epage><pages>625-628</pages><issn>0960-3271</issn><eissn>1477-0903</eissn><abstract>We report clinical findings and pharmacokinetic data regarding a combined dapsone and clofazimine intoxica tion in a man, who ingested 50 tablets of dapsone (100 mg), 20 capsules of clofazimine (100 mg) and two tablets of rifampicin (600 mg). Oral administration of activated charcoal (50 grams) and sodium sulphate (20 grams) after gastric lavage resulted in an elimination half-life in plasma of 11.1 and 10.8 h for dapsone and its main metabolite, monoacetyldapsone, respectively. A rapid initial decrease of the plasma concentration of clofazi mine was observed after gastric lavage and administration of activated charcoal and sodium sulphate. 15 h after this treatment, clofazimine plasma levels remained relatively constant. Dapsone-induced methaemoglobinaemia (48% at admission) was treated successfully with methylene blue.</abstract><cop>Thousand Oaks, CA</cop><pub>SAGE Publications</pub><pmid>8863056</pmid><doi>10.1177/096032719601500805</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0960-3271 |
| ispartof | Human & experimental toxicology, 1996-08, Vol.15 (8), p.625-628 |
| issn | 0960-3271 1477-0903 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_21066543 |
| source | SAGE Complete Deep Backfile Purchase 2012 |
| subjects | Adult Biological and medical sciences Charcoal Clofazimine - blood Clofazimine - poisoning Dapsone - analogs & derivatives Dapsone - blood Dapsone - poisoning Drug Overdose Drug toxicity and drugs side effects treatment Gastric Lavage Humans Leprostatic Agents - blood Leprostatic Agents - poisoning Male Medical sciences Methemoglobinemia - blood Methemoglobinemia - chemically induced Methemoglobinemia - drug therapy Methylene Blue - therapeutic use Pharmacology. Drug treatments Rifampin - poisoning Suicide, Attempted Sulfates - therapeutic use Toxicity: blood |
| title | Combined dapsone and clofazimine intoxication |
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