Modelling Dermal Pharmacokinetics Using in vitro Data Part I. Fluazifop-butyl in the Rat

The pharmacokinetics of the herbicide fluazifop-butyl have been determined in female rats following oral and intravenous dosing, and described by a mathematical model. Penetration of fluazifop-butyl through epidermal membranes has been determined using three different receptor fluids. It is demonstr...

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Bibliographic Details
Published in:Human & experimental toxicology 1993-05, Vol.12 (3), p.199-206
Main Authors: Auton, T.R., Ramsey, J.D., Woollen, B.H.
Format: Article
Language:English
Subjects:
Administration, Oral
Animals
Dose-Response Relationship, Drug
Drug Administration Schedule
Female
Herbicides - blood
Herbicides - pharmacokinetics
Herbicides - urine
Injections, Intravenous
Models, Biological
Pyridines - blood
Pyridines - pharmacokinetics
Pyridines - urine
Rats
Skin Absorption - drug effects
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Summary:The pharmacokinetics of the herbicide fluazifop-butyl have been determined in female rats following oral and intravenous dosing, and described by a mathematical model. Penetration of fluazifop-butyl through epidermal membranes has been determined using three different receptor fluids. It is demonstrated how this in vitro absorption data can be used with a pharmacokinetic model derived from oral and i.v. dosing studies to predict plasma concentrations and urinary excretion profiles following dermal dosing. Model predictions are compared with experimental measurements and found to be in good agreement.
ISSN:0960-3271
1477-0903
DOI:10.1177/096032719301200302