The Immunotoxicity of Tributyltin Oxide (TBTO) does not Increase the Susceptibility of Rats to Experimental Respiratory Infection

1 The dietary exposure of rats to tributyltin oxide at a concentration of 150 ppm for 6 weeks is known to lead to a significant reduction in relative thymic weight. 2 To determine whether this reduction in thymic weight also leads to an impairment of function sufficient to alter the host response to...

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Published in:Human & experimental toxicology 1992-03, Vol.11 (2), p.71-75
Main Authors: Carthew, P., Edwards, R.E., Dorman, B.M.
Format: Article
Language:English
Subjects:
Animals
Disease Susceptibility
Female
Male
Mycoplasma Infections - etiology
Mycoplasma pulmonis
Pneumonia - etiology
Pneumonia, Viral - etiology
Rats
Rats, Inbred Strains
Trialkyltin Compounds - toxicity
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description 1 The dietary exposure of rats to tributyltin oxide at a concentration of 150 ppm for 6 weeks is known to lead to a significant reduction in relative thymic weight. 2 To determine whether this reduction in thymic weight also leads to an impairment of function sufficient to alter the host response to micro-organisms, we have examined the development of virus- and mycoplasma-induced pneumonia in TBTO-exposed rats. 3 Using a quantitative histopathological method for measuring both the extent and duration of lung lesions in TBTO-exposed rats, no statistically significant increase in the extent or persistence of virus-induced lung lesions was found in rats exposed chronically to TBTO. 4 The susceptibility of rats to Mycoplasma pulmonis infection, alone, or in conjunction with viral pneumonia, was also not increased by dietary exposure to TBTO.
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subjects Animals
Disease Susceptibility
Female
Male
Mycoplasma Infections - etiology
Mycoplasma pulmonis
Pneumonia - etiology
Pneumonia, Viral - etiology
Rats
Rats, Inbred Strains
Trialkyltin Compounds - toxicity
title The Immunotoxicity of Tributyltin Oxide (TBTO) does not Increase the Susceptibility of Rats to Experimental Respiratory Infection
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